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Isoquinoline Alkaloid Contents in Macleaya cordata Extracts and Their Acetylcholinesterase and Butyrylcholinesterase Inhibition.

The study aimed to optimize a method for determining cholinesterase activity using high-performance liquid chromatography and then investigate the potential of isoquinoline alkaloids and plant extracts for inhibiting acetylcholinesterase and butyrylcholinesterase activity. The HPLC method successfully eliminated interference from certain alkaloids and allowed for identification of bioactive compounds in the plant extracts. Results showed high inhibition activity, particularly in sanguinarine and chelerythrine alkaloids and the May aerial plant extract. These extracts may be recommended for further in vivo testing to confirm cholinesterase inhibition activity.

Tuzimski T et al (2022).
Molecules.
PubMed:
35684539