All Studies

In-silico studies on wild orange (Citrus macroptera Mont.) compounds against COVID-19 pro-inflammation targets.

A study investigated phytochemicals from for their potential to inhibit inflammatory proteins that remain active in some COVID-19 survivors. Molecular docking analysis found promising inhibitory potential of the phytochemicals against COX-2, NMDAR, and VCAM-1, and MM-GBSA binding free energy estimation showed one candidate, Limonene, displayed the highest binding efficacy with VCAM-1. The study suggests that these natural compounds could be further validated in pre-clinical and clinical trials for potential use in treating post-COVID inflammation complications.

Lala M et al (2023).
J Biomol Struct Dyn.
PubMed:
35297321

Immunotoxical, neurotoxical, histopathological and immunohistopathological alterations of Nerium oleander and Tecoma stans methanolic extract on Biomphalaria alexandrina snails.

The study investigated the molluscicidal effects of extracts from Nerium oleander and Tecoma stans on B. alexandrina snails. Results showed that N. oleander had a stronger effect than T. stans, and the extracts had no negative effects on other organisms. Exposure to sub-lethal concentrations of the extracts caused a decrease in certain blood cell types and biochemical changes, as well as morphological alterations in snail organs. The extracts could be used as a safe and affordable alternative to synthetic molluscicides for controlling the spread of schistosomiasis.

Ibrahim AM et al (2022).
Acta Trop.
PubMed:
35296391