Chromosome-Scale Assembly of the Dendrobium nobile Genome Provides Insights Into the Molecular Mechanism of the Biosynthesis of the Medicinal Active Ingredient of Dendrobium.
- Xu Q et al (2022).
- Front Genet.
- PubMed:
- 35299950
A study investigated phytochemicals from for their potential to inhibit inflammatory proteins that remain active in some COVID-19 survivors. Molecular docking analysis found promising inhibitory potential of the phytochemicals against COX-2, NMDAR, and VCAM-1, and MM-GBSA binding free energy estimation showed one candidate, Limonene, displayed the highest binding efficacy with VCAM-1. The study suggests that these natural compounds could be further validated in pre-clinical and clinical trials for potential use in treating post-COVID inflammation complications.
The study investigated the molluscicidal effects of extracts from Nerium oleander and Tecoma stans on B. alexandrina snails. Results showed that N. oleander had a stronger effect than T. stans, and the extracts had no negative effects on other organisms. Exposure to sub-lethal concentrations of the extracts caused a decrease in certain blood cell types and biochemical changes, as well as morphological alterations in snail organs. The extracts could be used as a safe and affordable alternative to synthetic molluscicides for controlling the spread of schistosomiasis.