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Jatamansinol from Nardostachys jatamansi (D.Don) DC. Protects Aβ(42)-Induced Neurotoxicity in Alzheimer's Disease Drosophila Model.

A study analyzed the effect of jatamansinol, an active compound in an essential Indian Ayurvedic plant, on neuroprotection against Alzheimer's disease (AD) in a Drosophila AD model. Flies supplemented with jatamansinol showed extended lifespan, enhanced learning and memory, improved locomotor abilities, reduced Aβ protein levels, and prevented oxidative stress-induced eye degeneration and cholinesterase activities. Jatamansinol showed neuroprotective effects against Aβ protein-induced neurotoxicity in the AD model, suggesting its therapeutic potential against AD.

Anupama KP et al (2022).
Neurotoxicology.
PubMed:
35247505