Identification of promising multi-targeting inhibitors of obesity from Vernonia amygdalina through computational analysis.
- Ogunyemi OM et al (2023).
- Mol Divers.
- PubMed:
- 35179699
This study looked at the effects of Nardostachys jatamansi, a traditional Chinese medicine, on the gut microbiota of rats with Parkinson's disease. The researchers found that the extract improved behavior and reversed increased levels of proinflammatory cytokines and protein aggregation in the colon and striatum, indicating a potential neuroprotective effect. They also discovered a decrease in gut microbiota diversity and abundance in the PD model, and the extract increased the relative abundance of certain beneficial bacteria while reversing the increase of harmful ones. This study provides a basis for combining traditional and modern medicine to treat PD.
Researchers investigated the mechanism by which the medicinal plant Jivanti increases breast milk production. Dopamine D2 receptor (D2R) activation inhibits lactotroph cell prolactin synthesis. In-silico analysis of phytocompounds from Jivanti identified campesterol and β-sitosterol as having high binding affinity (-10.1 and -10.0 kcal/mol) with D2R and stable interaction for prolactin release, which may increase breast milk production. Campesterol had good solubility and absorption characteristics, making it a candidate medication for boosting breast milk production. Jivanti has traditionally been consumed by nursing mothers to improve breast milk production.