Rapid screening for acetylcholinesterase inhibitors in Selaginella doederleinii Hieron by using functionalized magnetic Fe(3)O(4) nanoparticles.

This study developed a new screening tool to find drugs to treat Alzheimer's disease by inhibiting acetylcholinesterase (AChE), an enzyme that deactivates the cognitive chemical acetylcholine. The researchers immobilized AChE on magnetic nanoparticles and optimized the process to maximize enzyme immobilization yield. They then used this tool to screen natural products and found four compounds that successfully inhibited AChE - one of which was more potent than the current treatment, tacrine. This approach could be useful for discovering target drugs from complex matrices.

Zhang F et al (2022).

Talanta.

DOI:

10.1016/j.talanta.2022.123284

PubMed:

35255433

The role of Gentiana lutea extracts in reducing UV-induced DNA damage.

Cvetković S et al (2022).

Mutagenesis.

DOI:

10.1093/mutage/geac006

PubMed:

35253882

Dealkenylation of neoandrographolide, a phytochemical from Andrographis paniculata stimulates FXR (Farnesoid X Receptor) and enhances gallstone dissolution.

Sharma R, Kumar K and Tanvi K (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2022.2048078

PubMed:

35253613

The complete chloroplast genome of Ananas comosus var. erectifolius (L.B. Smith) Coppens & Leal.

Liu C, Zhang W and He Y (2022).

Mitochondrial DNA B Resour.

DOI:

10.1080/23802359.2022.2039081

PubMed:

35252578

The complete chloroplast genome of the Chinese banyan tree Ficus microcarpa.

Lin E et al (2022).

Mitochondrial DNA B Resour.

DOI:

10.1080/23802359.2021.1993097

PubMed:

35252575

Transcriptome datasets of β-Aminobutyric acid (BABA)-primed mono- and dicotyledonous plants, Hordeum vulgare and Arabidopsis thaliana.

Hegedűs G et al (2022).

Data Brief.

DOI:

10.1016/j.dib.2022.107983

PubMed:

35252498

Effects of Momordica cochinchinensis Aril Extract on Sterilized Low-Fat Milk, Antioxidant and Antiproliferative Activities.

Anunthawan T et al (2022).

Int J Food Sci.

DOI:

10.1155/2022/7934454

PubMed:

35252438

Protective Effects of Alternanthera sessilis Ethanolic Extract against TNF-α or H(2)O(2)-Induced Endothelial Activation in Human Aortic Endothelial Cells.

Mohd Razali NN et al (2022).

Evid Based Complement Alternat Med.

DOI:

10.1155/2022/8738435

PubMed:

35251216