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Qing Fei Pai Du Tang (QFPDT), a Chinese medicine formula consisting of 21 herbs, has been reported to be effective in treating COVID-19. It has been shown to prevent the progression of mild cases and shorten hospital stays. The formula has been recommended in China's Clinical Practice Guideline on COVID-19. Basic scientific studies have identified QFPDT's anti-oxidation, immuno-modulation, and antiviral mechanisms, including cytokine storm prevention and angiotensin converting enzyme 2 (ACE2) receptor binding regulation. QFPDT's multi-target mechanisms for treating viral infections in general and COVID-19 in particular were validated. While large-scale clinical studies of QFPDT are ongoing, real-world data can be used to explore integrative treatment options, including herb-drug interactions.