All Studies

Unraveling the antifungal composition of bitter orange decoction against the melon pathogen Fusarium jinanense.

Researchers analyzed the antifungal properties of bitter orange peel decoction, identifying coumarins and flavones as key inhibitors of a melon phytopathogen. This study provides insights for utilizing unexplored food sources in drug development.

de Freitas MD et al (2024).
Food Chem.
PubMed:
38843716

Daphnoretin inhibited SCI-induced inflammation and activation of NF-κB pathway in spinal dorsal horn.

Daphnoretin, a compound from nature, shows potential in reducing inflammation and activating a key pathway after spinal cord injury. This research may lead to safer and more effective treatments for SCI.

Wu J, Lin F and Chen B (2024).
Aging (Albany NY).
PubMed:
38843384

Amentoflavone reverses epithelial-mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis.

Amentoflavone from Selaginella doederleinii reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting core genes and blocking the p53 signaling pathway, leading to reduced cell migration, invasion, and apoptosis. Important for potential cancer treatment strategies.

Jian HY et al (2024).
J Cell Mol Med.
PubMed:
38842135

Analyzing noncovalent interactions between notoginseng saponins and lysozyme by deposition scanning intensity fading MALDI-TOF mass spectrometry.

Improved IF-MALDI-MS method used to study binding of Panax notoginseng saponins with lysozyme. Results show binding affinity order and suggest hydrogen bonding role. Valuable for screening natural products for pharmacological activities.

Zhao X et al (2024).
J Mass Spectrom.
PubMed:
38842112

Antioxidant, antidiabetic, and anti-inflammatory activities of flavonoid-rich fractions of Solanum anguivi Lam. fruit: In vitro and ex vivo studies.

A study on flavonoids in fruits shows potential for treating diabetes due to antioxidant and anti-inflammatory properties, as well as inhibition of key enzymes. Fraction A is most effective. More research is needed for practical application.

Ojo AB and Adanlawo IG (2024).
Heliyon.
PubMed:
38841505

Therapeutic effect of Periploca forrestii on collagen-induced arthritis in rats through JAK2/Nf-κB pathway.

Chinese herbal medicine has potential therapeutic effects on rheumatoid arthritis, as confirmed through chemical analysis and testing on rats. Understanding its mechanisms could lead to new treatments for this chronic autoimmune disease.

Zhang Z et al (2024).
Front Pharmacol.
PubMed:
38841364

Species identification of biological ingredients in herbal product, Gurigumu-7, based on DNA barcoding and shotgun metagenomics.

Study used shotgun metabarcoding to accurately identify species in complex mixtures like pharmaceuticals. Detected bio-ingredients in Mongolian medicine G-7 and confirmed results with HPLC and PCR. Promising for mixture analysis.

Wei M et al (2024).
Front Plant Sci.
PubMed:
38841282

P-hydroxybenzaldehyde protects Caenorhabditis elegans from oxidative stress and β-amyloid toxicity.

Researchers studied the effects of -hydroxybenzaldehyde (-HBA) from on Alzheimer's disease treatment using animal models. -HBA has shown anti-inflammatory, antioxidative stress, and neuroprotective effects. This research may lead to new treatments for Alzheimer's.

Yu X et al (2024).
Front Aging Neurosci.
PubMed:
38841104