20206.
Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin.
The plant Polygala has previously been shown to protect against nerve cell death and cognitive impairment. Researchers tested three compounds from the plant against the toxic effects of mercury in mouse brain cells. One compound, quercetin, prevented mercury-induced damage to the cells' mitochondria and prevented glutathione oxidation. The study also revealed that mercury increased the production of hydrogen peroxide in the brain's mitochondria, which quercetin prevented. These findings highlight quercetin's potential as a protective agent against mercury poisoning and contribute to our understanding of the toxic effects of mercury on brain cells.
Franco JL et al (2007).
Chem Res Toxicol.