From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches.

Researchers investigated Saudi Arabian flora compounds in treating ovarian cancer, identifying key genes and pathways. Compounds like ascorbic acid and hispidulin showed promising interactions with AKT1 and VEGFA proteins, suggesting potential for future anti-cancer treatments.

Alblihy A et al (2024).

Front Pharmacol.

DOI:

10.3389/fphar.2024.1345415

PubMed:

38666020

The cardioprotective potential of selected species of mistletoe.

Mistletoe, especially L., may have cardioprotective properties for treating CVD. Further research is needed to understand its mechanisms, interactions with drugs, and determine therapeutic doses for clinical use.

Olas B et al (2024).

Front Pharmacol.

DOI:

10.3389/fphar.2024.1395658

PubMed:

38666019

Structure-based virtual screening of mangiferin derivatives with antidiabetic action: a molecular docking and dynamics study and MPO-based drug-likeness approach.

HMF and other mangiferin derivatives exhibit strong antidiabetic properties by inhibiting aldose reductase with promising drug-like properties and low toxicity. HMF stands out for its high affinity and stability, making it a promising candidate for diabetes treatment.

da Silva Lopes FF et al (2024).

3 Biotech.

DOI:

10.1007/s13205-024-03978-9

PubMed:

38665880

Metabolite profiling, antioxidant and anti-glycemic activities of Tartary buckwheat processed by solid-state fermentation(SSF)with Ganoderma lucidum.

Fermentation of Tartary buckwheat increased enzyme activity, bioactive compounds, and metabolite diversity. Results show improved antioxidant and anti-glycemic properties. Fermentation could enhance health benefits of Tartary buckwheat.

Zhang R et al (2024).

Food Chem X.

DOI:

10.1016/j.fochx.2024.101376

PubMed:

38665636

Comparing the differences in quality profiles and antioxidant activity in seven pumpkin cultivars (Cucurbita moschata and Cucurbita maxima) at harvest and during postharvest storage.

Xu Y et al (2024).

Food Chem X.

DOI:

10.1016/j.fochx.2024.101383

PubMed:

38665625

Impact of coconut kernel extract on carcinogen-induced skin cancer model: Oxidative stress, C-MYC proto-oncogene and tumor formation.

Coconut kernel extract (CKE) prevented skin tumor growth in mice by reducing oxidative stress and suppressing c-MYC overexpression. CKE showed higher antioxidant activity than ascorbic acid, making it a potential dietary antioxidant with anti-tumor properties.

Sandhya S et al (2024).

Heliyon.

DOI:

10.1016/j.heliyon.2024.e29385

PubMed:

38665592

Isolation, characterization and anti-inflammatory activity of compounds from the Vernonia amygdalina.

Atolani O et al (2024).

Heliyon.

DOI:

10.1016/j.heliyon.2024.e29518

PubMed:

38665563

Investigating the effects of Laggera pterodonta on H3N2-Induced inflammatory and immune responses through network pharmacology, molecular docking, and experimental validation in a mice model.

Chen Y et al (2024).

Heliyon.

DOI:

10.1016/j.heliyon.2024.e29487

PubMed:

38665556