All Studies

A fast and efficient method for screening and evaluation of hypoglycemic ingredients of Traditional Chinese Medicine acting on PTP1B by capillary electrophoresis.

Inhibitors of PTP1B, an enzyme involved in insulin signaling and diabetes, were screened using CE. Traditional Chinese Medicine showed strong inhibition, with fast analysis time, making it a valuable tool for drug discovery.

Gao J et al (2024).
J Pharm Biomed Anal.
PubMed:
38554553

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling.

23-HBA from P. chinensis inhibits M2 macrophage polarization, decreasing resistance to 5-FU in colorectal cancer. Suppresses IL-10/STAT3/Bcl-2 pathway, enhancing 5-FU efficacy and reducing M2 macrophage presence in tumor tissues.

Fan Z et al (2024).
Cancer Immunol Immunother.
PubMed:
38554148

Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate-protein kinase G signaling in diabetic mice.

Researchers studied the potential benefits of Polygonatum sibiricum polysaccharide (PSP) in treating diabetic cardiomyopathy (DCM) in mice. Results may lead to new treatments for this common condition in diabetic individuals.

Lei S et al (2024).
J Diabetes Investig.
PubMed:
38553792

Unveiling the antibacterial and antifungal potential of biosynthesized silver nanoparticles from Chromolaena odorata leaves.

Biogenesis of silver nanoparticles using Chromolaena odorata leaf extract shows potential as antibacterial and antifungal agents. Promising results suggest possible use in treating challenging fungal infections, with future potential for novel antifungal therapies.

Bishoyi AK et al (2024).
Sci Rep.
PubMed:
38553574