Identification of antiviral phytochemicals from cranberry as potential inhibitors of SARS-CoV-2 main protease (M(pro)).

Researchers identified cranberry phytochemicals with antiviral activity against SARS-CoV-2 main protease. Lead compounds were cyanidin 3-O-galactoside, β-carotene, and epicatechin. Cyanidin showed the highest inhibitory potential. Cranberry extracts containing anthocyanins also exhibit potential. Used for therapeutic interventions against SARS-CoV-2.

Pillai U J et al (2024).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2024.129655

PubMed:

38266830

Pharmacokinetics and metabolite identification of 23-hydroxybetulinic acid in rats by using liquid chromatography-mass spectrometry method.

Xue M et al (2024).

J Chromatogr B Analyt Technol Biomed Life Sci.

DOI:

10.1016/j.jchromb.2024.124016

PubMed:

38266610

Comprehensive investigation of BZR gene family in four dicots and the function of PtBZR9 and PtBZR12 under drought stress.

Wang L et al (2024).

Plant Physiol Biochem.

DOI:

10.1016/j.plaphy.2024.108360

PubMed:

38266559

Efficient Production of Flavonoid Glucuronides in Escherichia coli Using Flavonoid O-Glucuronosyltransferases Characterized from Marchantia polymorpha.

Du NH et al (2024).

J Nat Prod.

DOI:

10.1021/acs.jnatprod.3c00880

PubMed:

38266493

Uncovering the colorectal cancer immunotherapeutic potential: Evening primrose (Oenothera biennis) root extract and its active compound oenothein B targeting the PD-1/PD-L1 blockade.

Immune checkpoint inhibitors (such as PD-L1/PD-1 blockers) are effective immunotherapy drugs for cancer treatment, but their side effects restrict their use. FDA only permits monoclonal antibody-based PD-L1/PD-1 blockers.

Lee EJ et al (2024).

Phytomedicine.

DOI:

10.1016/j.phymed.2024.155370

PubMed:

38266440

Genome-wide analysis and expression divergence of protein disulfide isomerase (PDI) gene family members in chickpea (Cicer arietinum) under salt stress.

Parveen K et al (2024).

Funct Plant Biol.

DOI:

10.1071/FP23253

PubMed:

38266276

Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability.

Researchers have discovered that a lectin, PHA, can increase the effectiveness of chemotherapy drugs on lung cancer cells by inhibiting autophagy, promoting apoptosis, and increasing drug concentration inside cells, potentially overcoming drug resistance.

Wang P et al (2024).

J Nat Med.

DOI:

10.1007/s11418-023-01772-0

PubMed:

38265611

Effect of Nigella sativa Consumption on Lipid Profile and Glycemic Index in Patients with Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Study on the effects of Nigella sativa on lipid profile and glycemic indices in metabolic syndrome patients. Meta-analysis of randomized trials highlights its potential benefits in managing the condition.

Shabani M et al (2024).

Curr Med Chem.

DOI:

10.2174/0109298673249741231129100733

PubMed:

38265398