Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn.

Researchers used a model to identify four potential EGFR antagonists in Silybum marianum, showing potential for new, efficient, and less toxic cancer treatment.

Zhang X et al (2023).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2023.115816

PubMed:

37976988

Selective and reliable fluorometric quantitation of anti-cancer drug in real plasma samples using nitrogen-doped carbon dots after MMIPs solid phase microextraction: Monitoring methotrexate plasma level.

Researchers synthesized a fluorescence probe for precise quantitation of methotrexate (MTX). The probe showed a wide detection range, high sensitivity, and selectivity. It was successfully applied for quantification of MTX in rabbit plasma samples, with potential for pharmaceutical applications.

Alanazi AZ et al (2023).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2023.115862

PubMed:

37976985

Molecular characterization of genes involved in tolerance of cadmium in Triticum aestivum (L.) under Cd stress.

Rasheed A et al (2024).

J Hazard Mater.

DOI:

10.1016/j.jhazmat.2023.132955

PubMed:

37976857

Malate production, sugar metabolism, and redox homeostasis in the leaf growth zone of Rye (Secale cereale) increase stress tolerance to aluminum stress: A biochemical and genome-wide transcriptional study.

This study shows that global soil acidification is increasing aluminum availability, hindering plant growth. It identifies genes associated with stress response and detoxification in rye, suggesting that Al tolerance is linked to exclusion from leaf meristem.

Donnelly CP et al (2023).

J Hazard Mater.

DOI:

10.1016/j.jhazmat.2023.132956

PubMed:

37976853

Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication.

Compounds from the hop plant, including xanthohumol, have strong antiviral effects. XN specifically shows promise in inhibiting the main protease of SARS-CoV-2. This could be valuable for developing potential treatments against COVID-19.

Herzog AM et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155176

PubMed:

37976697

Integrating bioinformatics and experimental models to investigate the mechanism of the chelidonine-induced mitotic catastrophe via the AKT/FOXO3/FOXM1 axis in breast cancer cells.

Chelidonine, an ingredient in Chelidonium majus, can trigger mitotic catastrophe in breast cancer (BC) cells. FOXO3 is a potential biomarker for BC prognosis, and chelidonine inhibits BC cell proliferation, induces M phase arrest, and weakens the AKT/FOXO3/FOXM1 axis, making it a promising treatment for BC.

Li H et al (2023).

Biomol Biomed.

DOI:

10.17305/bb.2023.9665

PubMed:

37976368

Smells like lemons: MYB-ADH gene cluster regulates citral biosynthesis in Litsea cubeba.

Kazachkova Y et al (2023).

Plant Physiol.

DOI:

10.1093/plphys/kiad617

PubMed:

37976167

Hippophae rhamnoides Prevents Oleic Acid-Induced Acute Respiratory Distress Syndrome by Releasing Acetylcholinesterase Activity and Mitigation of Angiotensin-Converting Enzyme Level.

This study investigated the effects of an ethanol extract on acute respiratory distress syndrome (ARDS) in rats. The extract reduced inflammation, oxidative stress, and apoptosis, indicating its potential as a protective treatment for ARDS.

Koc K et al (2023).

J Med Food.

DOI:

10.1089/jmf.2023.0150

PubMed:

37976106