Genome-wide dissection and haplotype analysis identified candidate loci for nitrogen use efficiency under drought conditions in winter wheat.

Climate change impacts wheat yield through drought and nutrient imbalances. Research on 200 wheat genotypes identified genetic variations in response to drought and nitrogen stress, revealing QTLs linked to these factors. Contrasting haplotypes on chromosomes 1B and 5A affect nitrogen uptake and use efficiency, and a candidate gene for cold shock protein was implicated. These findings could aid the development of diagnostic markers for drought tolerance and nitrogen use efficiency in wheat.

Koua AP et al (2023).

Plant Genome.

DOI:

10.1002/tpg2.20394

PubMed:

37880495

Steroid and triterpenoid saponins from the rhizomes of Paris polyphylla var. stenophylla.

Scientists discovered five new saponins from Paris polyphylla var. stenophylla. One of the compounds showed potential inhibitory effect on three glioma cell lines.

Hu J et al (2023).

Chin J Nat Med.

DOI:

10.1016/S1875-5364(23)60486-8

PubMed:

37879796

Tripterygium hypoglaucum extract ameliorates adjuvant-induced arthritis in mice through the gut microbiota.

Hu J et al (2023).

Chin J Nat Med.

DOI:

10.1016/S1875-5364(23)60466-2

PubMed:

37879792

Integrated network pharmacology and metabolomics to investigate the effects and possible mechanisms of Dehydroevodiamine against ethanol-induced gastric ulcers.

Researchers investigated the effect of dehydroevodiamine (DHE), a compound found in traditional Chinese medicine Tetradium ruticarpum, on ethanol-induced gastric ulcers. DHE has previously shown anti-inflammatory, analgesic, and antioxidant effects. Understanding its impact on gastric ulcers may have implications for treating such conditions.

Wang X et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117340

PubMed:

37879508

In vitro anti-severe acute respiratory syndrome coronavirus 2 effect of Ephedra przewalskii Stapf extract.

The study explores the potential of Ephedra przewalskii extract as a treatment for infectious diseases. While E. sinica extract is used in traditional medicines, it has side effects. E. przewalskii extract is ephedrine-free but lacks sufficient evidence for its antiviral efficacy.

Kakimoto M et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117341

PubMed:

37879507

Understanding apoptotic induction by Sargentodoxa cuneata-Patrinia villosa herb pair via PI3K/AKT/mTOR signalling in colorectal cancer cells using network pharmacology and cellular studies.

This study investigated the specific anticancer ingredients and mechanism of action of Sargentodoxa cuneata and Patrinia villosa in combination for colorectal cancer treatment. Results could provide insights for developing effective therapies.

Mu BX et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117342

PubMed:

37879505

The JAK/STAT/NF-κB signaling pathway can be regulated by rosemary essential oil, thereby providing a potential treatment for DNCB-induced in mice.

This study explores how rosemary essential oil helps treat atopic dermatitis, offering insights for potential therapeutic applications in managing the condition.

Li J et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.115727

PubMed:

37879216

Inhibiting NF-κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer.

Demethylzeylasteral, a natural compound derived from Tripterygium wilfordii, has shown potent anti-colon cancer activity. This study identifies S100A11 as a target protein and NF-κB as a regulator of S100A11 expression, highlighting the potential of demethylzeylasteral for anti-tumor therapy.

Li W et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.115725

PubMed:

37879212