Efficacy and safety of purslane (Portulaca oleracea) for mild to moderate chronic hand eczema; A randomized, double-blind, placebo-controlled clinical trial.

Heydarirad G et al (2023).

Explore (NY).

DOI:

10.1016/j.explore.2023.10.005

PubMed:

37872023

Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.

Researchers discovered that a compound called berberrubine, found in Coptis chinensis, selectively inhibits IMPDH2, a protein highly expressed in colorectal cancer. Berberrubine impairs cancer cell growth and reduces tumor size in cells and mouse models, indicating potential for CRC treatment.

He X et al (2023).

Biochem Pharmacol.

DOI:

10.1016/j.bcp.2023.115868

PubMed:

37871880

Root Extract of Trichosanthes kirilowii Suppresses Metastatic Activity of EGFR TKI-Resistant Human Lung Cancer Cells by Inhibiting Src-Mediated EMT.

Researchers investigated the effects of an ethanolic root extract of TK (ETK) on metastatic lung cancer cells resistant to EGFR tyrosine kinase inhibitors. ETK reduced migration and invasion and suppressed EMT by dephosphorylating Src. CuB played a key role in ETK's anti-metastatic activity. ETK could be a potential treatment for EGFR-TKI-resistant lung cancer.

Park HJ and Park SH (2023).

Nutr Cancer.

DOI:

10.1080/01635581.2023.2272345

PubMed:

37870977

The first two chromosome-scale genome assemblies of American hazelnut enable comparative genomic analysis of the genus Corylus.

Brainard SH et al (2023).

Plant Biotechnol J.

DOI:

10.1111/pbi.14199

PubMed:

37870930

Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.

Scientists found that morusinol, a compound from L., has potential as an anticancer agent for colorectal cancer. It inhibits cell growth, promotes cell death, and induces autophagy in cancer cells by affecting cholesterol metabolism. Animal models confirmed its ability to impede tumor growth, making it a potential candidate for CRC treatment.

Zhang X et al (2023).

J Agric Food Chem.

DOI:

10.1021/acs.jafc.3c01244

PubMed:

37870273

The ability of supercritical CO(2) carrot and pumpkin extracts to counteract inflammation and oxidative stress in RAW 264.7 macrophages stimulated with LPS or MDA-MB-231 cell-conditioned media.

Frattaruolo L et al (2023).

Food Funct.

DOI:

10.1039/d3fo03159d

PubMed:

37870074

In-silico studies of Brassica oleracea active compounds and their role in thyroid peroxidase activity.

Scientists studied the potential anti-thyroid effects of compounds in cabbage. Only 18 out of 60 compounds showed strong binding with the target. Gamma-Terpinene, a monoterpene, had the highest binding energy and met all criteria. Cooked cabbage might have diminished anti-thyroid effects due to the degradation of gamma-Terpinene.

Kalath H et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2270601

PubMed:

37870072

Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF-α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats.

Researchers investigated the potential of Swertia chirayita, Trigonella foenum-gracum, and Sesamum indicum in treating diabetes. Understanding the role of innate immunity and inflammation in diabetes-related microvascular problems is crucial.

Shivam and Gupta AK (2023).

Curr Drug Discov Technol.

DOI:

10.2174/0115701638252203230919092315

PubMed:

37870057