Evaluation of berberine nanoparticles as a strategy to modulate acetylcholinesterase activity.
Berberine-loaded solid dispersions (SD) show potential as inhibitors of acetylcholinesterase enzyme (AChE) for neurodegenerative disease treatment, with improved water solubility and cytotoxic effects on tumoral cells. The berberine SD also demonstrated no cytotoxicity/genotoxicity in testing, suggesting it could be a safe option.
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- Food Res Int.
- PubMed:
- 37803607