Catharanthus roseus (L.) G. Don counteracts the ampicillin resistance in multiple antibiotic-resistant Staphylococcus aureus by downregulation of PBP2a synthesis.
Researchers evaluated the mechanism by which an extract from the root of the medicinal plant (L.) G. Don reverses ampicillin resistance in . The extract caused DNA damage, reduced plasmid band intensities, and decreased the expression of PBP2a protein, making the bacteria susceptible to the antibiotic ampicillin.
- Shil A et al (2023).
- Open Life Sci.
- PubMed:
- 37772260