All Studies

Oxindole and Benzoxazinone Alkaloids from the Seeds of Persea americana (Avocado) and Their SIRT1 Stimulatory Activity.

Scientists studied the chemical components of avocado seeds and discovered nine new compounds. One of these compounds showed potential as an anti-aging agent, specifically activating SIRT1. Further investigation is recommended.

Phytochemistry Persea americana
Doan TP et al (2023).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.3c00214
PubMed:
37792632

Apoptotic activity of genipin in human oral squamous cell carcinoma in vitro by regulating STAT3 signaling.

Genipin, a compound from Gardenia jasminoides fruit, inhibits growth of oral squamous cell carcinoma (OSCC) cells by inducing apoptosis via caspase-dependent pathway and reducing STAT3 phosphorylation. It may be a potential therapeutic option for OSCC treatment.

Immunology Gardenia jasminoides
Park DG et al (2023).
Cell Biochem Funct.
DOI:
10.1002/cbf.3866
PubMed:
37792550

Genome sequence of Hemileia vastatrix Berk. and Br. (Race I), the causal agent of coffee leaf rust, isolate from Risaralda, Colombia.

Scientists used advanced sequencing techniques to assemble the genome of the coffee leaf rust fungus, a destructive global disease. This comprehensive genome can provide valuable insights for developing strategies to combat the disease and protect coffee crops.

Genetics Coffea arabica
Ángel C CA, Marín-Ramírez GA and Maldonado CE (2023).
Microbiol Resour Announc.
DOI:
10.1128/MRA.00444-23
PubMed:
37791781

Unveiling Alternative Oxidation Pathways and Antioxidant and Cardioprotective Potential of Amaranthin-Type Betacyanins from Spinach-like Atriplex hortensis var. 'Rubra'.

Advanced analytical techniques were used to investigate the oxidation mechanism of betacyanins. Alternative pathways and antioxidant oxidation products were discovered, with potential protective effects against cell death, providing insights into the biological activities of these compounds.

CardiologyImmunology Spinacia oleracea
Kumorkiewicz-Jamro A et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c03044
PubMed:
37791532

Metabolomics and transcriptomics analyses for characterizing the alkaloid metabolism of Chinese jujube and sour jujube fruits.

Researchers investigated the synthesis and metabolism of alkaloids in jujube fruits, focusing on Chinese jujube and sour jujube. Understanding these mechanisms could contribute to the economic value and potential benefits of jujube fruits.

GeneticsPhytochemistry Ziziphus jujuba
Xue X et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1267758
PubMed:
37790781

Reversing the escape from herbivory: Knockout of cardiac glycoside biosynthesis in wormseed wallflower ( Erysimum cheiranthoides L., Brassicaceae).

Wallflowers produce glucosinolates and cardiac glycosides to defend against herbivores. Knocking out enzymes involved in cardiac glycoside biosynthesis makes them susceptible to herbivory. Specialist herbivores are unable to feed on wallflowers without cardiac glycosides.

CardiologyPhytochemistry Erysimum cheiranthoides
Younkin GC et al (2023).
bioRxiv.
DOI:
10.1101/2023.09.19.558517
PubMed:
37790475

Quantification of Caffeoylquinic Acids and Triterpenes as Targeted Bioactive Compounds of Centella asiatica in Extracts and Formulations by Liquid Chromatography Mass Spectrometry.

Researchers developed an analytical method to accurately quantify 12 bioactive compounds in Centella asiatica (CA), a widely used culinary vegetable and medicinal herb. This method can support the standardization of CA products for clinical trials and confirm correct levels of CA phytochemical markers in preclinical diets.

Phytochemistry Centella asiatica
Yang L et al (2023).
J Chromatogr Open.
DOI:
10.1016/j.jcoa.2023.100091
PubMed:
37789901

The effects of Rhus coriaria L. (sumac) and Cinnamomum zeylanicum L. bark on serum cytokine levels in rat mammary carcinogenesis.

The researchers investigated the effects of sumac and cinnamon bark on serum cytokine levels in a rat model of breast cancer. Both substances demonstrated anti-inflammatory effects and potential anticancer activities.

Immunology Rhus coriaria
Sadlonova V et al (2023).
Neoplasma.
DOI:
10.4149/neo_2023_230405N186
PubMed:
37789780
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