Safety and antidiabetic activity of Lagenaria siceraria (Molina) Standl. juice in streptozotocin -induced diabetic rats.

Researchers investigated the potential antidiabetic effects and toxicity of Lagenaria siceraria (Molina) Standl. Juice. This has implications for developing affordable and safer dietary alternatives for diabetes management in India.

Das MJ et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117111

PubMed:

37673199

Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: touch-evoked response and light/dark transition.

Zebrafish study shows two Chinese herbal products had behavioral effects, suggesting combination assays as useful for safety assessment.

Romero NG et al (2023).

Reprod Toxicol.

DOI:

10.1016/j.reprotox.2023.108469

PubMed:

37673194

Solasonine ameliorates cerebral ischemia-reperfusion injury via suppressing TLR4/MyD88/NF-κB pathway and activating AMPK/Nrf2/HO-1 pathway.

Solasonine (SS), the main ingredient in Solanum nigrum L., shows neuroprotective effects in vitro and in vivo models of cerebral ischemia/reperfusion injury (CIRI). It reduces inflammation, oxidative stress, and apoptosis in neurons, and improves neurological outcomes in rats. Mechanistically, it targets the TLR4/MyD88/NF-κB and AMPK/Nrf2/HO-1 pathways.

Huo K et al (2023).

Int Immunopharmacol.

DOI:

10.1016/j.intimp.2023.110862

PubMed:

37672972

Metabolome and transcriptome analyses identify the characteristics and expression of related saponins of the three genealogical plants of bead ginseng.

Ye Y et al (2023).

PeerJ.

DOI:

10.7717/peerj.16034

PubMed:

37671355

Genome assembly of Polygala tenuifolia provides insights into its karyotype evolution and triterpenoid saponin biosynthesis.

Meng F et al (2023).

Hortic Res.

DOI:

10.1093/hr/uhad139

PubMed:

37671073

Genome-wide analysis of the R2R3-MYB gene family in Spatholobus suberectus and identification of its function in flavonoid biosynthesis.

Qin S et al (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1219019

PubMed:

37670861

Genome-wide identification and molecular evolution of NAC gene family in Dendrobium nobile.

Fu C and Liu M (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1232804

PubMed:

37670854

The Effect of Aloe Vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial.

This study analyzed the effects of aloe vera gel on healing diabetic foot ulcers due to the lack of affordable treatments. Understanding its impact can help develop alternative therapies for managing this costly and severe complication of diabetes.

Irani PS et al (2023).

Curr Drug Discov Technol.

DOI:

10.2174/1570163820666230904150945

PubMed:

37670716