Total flavonoids of Hippophae rhamnoides L. improves type 2 diabetes symptoms in rats through down-regulating of the DAG/PRKCA/MAPK10/p65/TNF-α signalling pathway.

This study investigates the chemical features, active ingredients, and anti-diabetes mechanism of Hippophae rhamnoides fruit. Results provide insights for its traditional use in diabetes treatment.

Yang X et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116962

PubMed:

37499844

AIEE activated Pyrene-Dansyl coupled FRET probe for discriminating detection of lethal Cu(2+) and CN(-): Bio-Imaging, DNA binding studies and prompt prognosis of Menke's disease.

Paul S et al (2023).

Spectrochim Acta A Mol Biomol Spectrosc.

DOI:

10.1016/j.saa.2023.123110

PubMed:

37499469

Smilagenin induces expression and epigenetic remodeling of BDNF in alzheimer's disease.

Smilagenin, found in Chinese medicinal herbs, increases BDNF expression in brain cells, which is important for their growth and survival.

Yang S et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.154956

PubMed:

37499345

Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity.

Researchers investigated the potential of the drug artesunate in treating intestinal mucositis, a common side effect of the chemotherapy drug 5-FU in colorectal cancer patients. Artesunate has shown effectiveness against various health conditions. This study aimed to find new treatments for 5-FU side effects.

Xia J et al (2023).

Discov Oncol.

DOI:

10.1007/s12672-023-00747-7

PubMed:

37498338

Polyphenol Bioaccessibility and Antioxidant Activity of Pomegranate (Punica granatum) Peel Supplementation in Diet-Induced Obese Rats.

This study tested the effect of pomegranate peel supplementation on obese rats. Pomegranate peel increased antioxidant capacity in the rats despite diminishing phenolic compounds after digestion.

Mellado-Negrete A et al (2023).

J Med Food.

DOI:

10.1089/jmf.2023.0051

PubMed:

37498320

Development of Pegylated Nano-Phytosome Formulation with Oleuropein and Rutin to Compare Anti-Colonic Cancer Activity with Olea Europaea Leaves Extract.

Olive leaf extract contains oleuropein and rutin, which have potential as cancer treatments. Loading them into PEGylated Nano-phytosomes enhances their effectiveness and stability, making them promising options for tumor-targeted therapy.

Mahmood TH et al (2023).

Chem Biodivers.

DOI:

10.1002/cbdv.202300534

PubMed:

37498138

Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway.

Arjunolic acid is a natural compound found in a plant called Combretaceae. It has cardiovascular protective effects, but we don't know how it works exactly.

Hasan MM et al (2023).

Pharm Biol.

DOI:

10.1080/13880209.2023.2230251

PubMed:

37497554

Heterologous Production of Artemisinin in Physcomitrium patens by Direct in vivo Assembly of Multiple DNA Fragments.

Ikram NKK et al (2023).

Bio Protoc.

DOI:

10.21769/BioProtoc.4719

PubMed:

37497445