Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease.

Scientists found that Corynoxine B (Cory B), a natural alkaloid, enhances autophagy to promote clearance of abnormal protein aggregates in Parkinson's disease. Cory B binds to HMGB1/2, increases Beclin 1/VPS34 complex activity, and improves behavioral abnormalities in PD animal models, suggesting its neuroprotective potential.

Zhu Q et al (2023).

Acta Pharm Sin B.

DOI:

10.1016/j.apsb.2023.03.011

PubMed:

37425041

The Effect and Safety Assessment of Metformin and DLBS3233 (A Bioactive Fraction of Lagerstroemia speciosa and Cinnamomum burmannii) on Improving Metabolic Parameters in Women with Polycystic Ovary Syndrome.

This study tested the effectiveness and safety of DLBS3233, a new insulin-sensitizing drug derived from Indonesian herbals, alone and in conjunction with metformin, in women with PCOS and insulin resistance.

Hidayat ST et al (2023).

Int J Womens Health.

DOI:

10.2147/IJWH.S409685

PubMed:

37424700

Incorporating oregano (Origanum vulgare L.) Essential oil onto whey protein concentrate based edible film towards sustainable active packaging.

Sajimon A et al (2023).

J Food Sci Technol.

DOI:

10.1007/s13197-023-05763-7

PubMed:

37424588

Effects of exogenous indole-3-acetic acid on the density of trichomes, expression of artemisinin biosynthetic genes, and artemisinin biosynthesis in Artemisia annua.

Guo Z et al (2023).

Biotechnol Appl Biochem.

DOI:

10.1002/bab.2489

PubMed:

37424116

Quinolinones Alkaloids with AChE Inhibitory Activity from Mangrove Endophytic Fungus Penicillium citrinum YX-002.

Liu Y et al (2023).

Chem Biodivers.

DOI:

10.1002/cbdv.202300735

PubMed:

37423890

Phylogenomics reveals extreme gene tree discordance in a lineage of dominant trees: hybridization, introgression, and incomplete lineage sorting blur deep evolutionary relationships despite clear species groupings in Eucalyptus subgenus Eudesmia.

McLay TGB et al (2023).

Mol Phylogenet Evol.

DOI:

10.1016/j.ympev.2023.107869

PubMed:

37423562

Zanthoxylum bungeanum amides ameliorates nonalcoholic fatty liver via regulating gut microbiota and activating AMPK/Nrf2 signaling.

Peng W et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116848

PubMed:

37423515

Anti-inflammatory, anticholinesterase, antioxidant, and memory enhancement potential of Phyllanthus amarus in potassium-dichromate induced neurotoxicity of male Wistar rats.

A study discovered that APALE, derived from Phyllanthus amarus, can protect against neurotoxicity caused by PDc. It improves cognitive function, regulates antioxidants and GABA levels, and reduces neuroinflammation, suggesting its potential as a neurotoxicity treatment.

Afoke IK, Judah GT and Marvelous OO (2023).

J Chem Neuroanat.

DOI:

10.1016/j.jchemneu.2023.102308

PubMed:

37423467