Bioprocessing of camptothecin from Alternaria brassicicola, an endophyte of Catharanthus roseus, with a strong antiproliferative activity and inhibition to Topoisomerases.

El-Hady NAAA et al (2024).

Microb Cell Fact.

DOI:

10.1186/s12934-024-02471-5

PubMed:

39060918

Neuroprotective properties of the Lilium brownii extracts in the experimental model of Parkinson's disease.

L. brownii extracts improve motor dysfunction, increase neuron count, reduce oxidative stress, and modulate p62-Keap1-Nrf2 pathway in PD mice. Ethanol extract more effective due to higher phenolic acid glyceride content.

Hui C et al (2024).

Metab Brain Dis.

DOI:

10.1007/s11011-024-01397-6

PubMed:

39060803

Antitumor activity of Polygonatum sibiricum polysaccharides.

Scientists studied Polygonatum sibiricum polysaccharide (PSP) for its potential in cancer treatment due to its diverse pharmacological activities. PSP shows promise as an immunomodulatory, antitumor, antioxidant, and anti-aging agent, but further research is needed to understand its complex mechanisms.

Lai W et al (2024).

Arch Pharm Res.

DOI:

10.1007/s12272-024-01511-3

PubMed:

39060656

Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.

Geniposide (GE) from Gardenia Jasminoides reduces cardiac oxidative stress, inflammation, fibrosis, and metabolic disturbances in heart failure with preserved ejection fraction (HFpEF) models. It targets MMP2/SIRT1/GSK3β pathway, showing potential as a treatment for HFpEF.

Han YL et al (2024).

Acta Pharmacol Sin.

DOI:

10.1038/s41401-024-01341-5

PubMed:

39060523

Genome-wide identification and expression profiling of growth‑regulating factor (GRF) and GRF‑interacting factor (GIF) gene families in chickpea and pigeonpea.

Khisti M et al (2024).

Sci Rep.

DOI:

10.1038/s41598-024-68033-2

PubMed:

39060385

Disinfectant efficacy of glabridin against dried and biofilm cells of Listeria monocytogenes and the impact of residual organic matter.

Glabridin from liquorice roots effectively disinfects L. monocytogenes, especially on stainless steel surfaces. Efficacy may vary with different food residues. Potential as a natural surface disinfectant.

Bombelli A et al (2024).

Food Res Int.

DOI:

10.1016/j.foodres.2024.114613

PubMed:

39059895

Jujuboside A through YY1/CYP2E1 signaling alleviated type 2 diabetes-associated fatty liver disease by ameliorating hepatic lipid accumulation, inflammation, and oxidative stress.

Ju A, an active component of SZS, protected against liver damage in T2DM by reducing lipid accumulation and inflammation, and enhancing fatty acid metabolism through PPARα activation. Potential treatment for NAFLD.

Zhang W et al (2024).

Chem Biol Interact.

DOI:

10.1016/j.cbi.2024.111157

PubMed:

39059604

RsOBP2a, a member of OBF BINDING PROTEIN transcription factors, inhibits two chlorophyll degradation genes in green radish.

Ying J et al (2024).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2024.134139

PubMed:

39059533