Asthma Studies

In silico network pharmacology analysis and molecular docking validation of Swasa Kudori tablet for screening druggable phytoconstituents of asthma.

This study investigates a traditional Siddha medicine called Swasa Kudori Tablet for treating asthma. The active compounds are identified and their gene targets are determined. Pinocembrin is found to have strong binding affinity with a target protein. Traditional medicines could be useful in developing new asthma treatments.

Asthma Piper nigrum
Sekaran K et al (2024).
Adv Protein Chem Struct Biol.
DOI:
10.1016/bs.apcsb.2023.07.001
PubMed:
38220427

Thymus vulgaris ameliorates cough in children with asthma exacerbation: a randomized, triple-blind, placebo-controlled clinical trial.

Study aims to determine if (TV) has an effect on cough in children (5-12 years) with mild to moderate asthma exacerbation. Relevant for understanding potential impact of TV on respiratory symptoms in asthmatic children.

Asthma Thymus vulgaris
Eskandarpour E et al (2024).
Allergol Immunopathol (Madr).
DOI:
10.15586/aei.v52i1.964
PubMed:
38186189

Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf.

PF leaf, a traditional Chinese medicine, improves lung function and reduces inflammation in a mouse model of allergic asthma. It targets 50 core proteins and the MAPK signaling pathway, potentially offering a treatment option for allergic asthma.

AsthmaImmunology Perilla frutescens
Cao M et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22971
PubMed:
38163225

Exploring Asthma Mechanism of Belamcanda Chinensis by "Dose-effect Weighted Coefficient" Network Pharmacology and Experiment Validation.

Belamcanda chinensis (BC), a traditional Chinese medicine, has anti-inflammatory and immune regulatory properties that can help counteract asthma, a serious and chronic inflammatory disease of the airways. This research is important for finding potential treatments for asthma.

Asthma Belamcanda chinensis
Zhang K et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/0113862073254607231107074015
PubMed:
38155401

A comprehensive study of Ephedra sinica Stapf-Schisandra chinensis (Turcz.) Baill herb pair on airway protection in asthma.

Mahuang and Wuweizi herbs, commonly used in traditional Chinese medicine for respiratory symptoms, work together to improve efficacy in treating cough and asthma. The mechanism against asthma is still unknown.

Asthma Ephedra sinicaSchisandra chinensis
Zhuo Z et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117614
PubMed:
38113990

Optimal molecular binding data and pharmacokinetic profiles of novel potential triple-action inhibitors of chymase, spleen tyrosine kinase, and prostaglandin D2 receptor in the treatment of asthma.

Scientists used molecular modeling to identify bioactive compounds in Chromolaena odorata that bind tightly to proteins implicated in asthma. This could lead to the development of small molecule inhibitors for asthma treatment with minimal side effects.

Asthma Chromolaena odorata
Akinnusi PA et al (2023).
J Genet Eng Biotechnol.
DOI:
10.1186/s43141-023-00577-8
PubMed:
37947895

Inhalation of Spray-Dried Extract of Salvia rosmarinus Spenn Alleviates Lung Inflammatory, Oxidative, and Remodeling Changes in Asthmatic Rats.

Researchers investigated the effects of rosemary extract on airway inflammation in asthmatic rats. The extract showed anti-oxidative and anti-inflammatory properties, suggesting that it could be beneficial for treating respiratory conditions.

AsthmaImmunology Salvia rosmarinus
Rajizadeh MA et al (2023).
Pharmacology.
DOI:
10.1159/000534392
PubMed:
37918369
1 2 3 4 11