Asthma Studies

The Role of Long-Acting Antimuscarinic Agents in the Treatment of Asthma.

This review discusses the history and effectiveness of antimuscarinic agents in asthma treatment. Tiotropium, glycopyrronium, and umeclidinium are recommended as add-on therapies for patients with severe asthma.

Asthma Datura stramonium
Arslan B, Çetin GP and Yilmaz İ (2023).
J Aerosol Med Pulm Drug Deliv.
DOI:
10.1089/jamp.2022.0059
PubMed:
37428619

Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.

Houttuynia cordata is a herbal compound from China with anti-inflammatory, antiviral, and antioxidant properties. It can potentially help in asthma treatment by targeting NLRP3 inflammasome.

Asthma Houttuynia cordata
Li M et al (2023).
Mol Immunol.
DOI:
10.1016/j.molimm.2023.06.013
PubMed:
37413910

Modulation of Immunological, Biochemical, and Histopathological Changes of Airway Remodeling by Withania somnifera in an Experimental Model of Allergic Asthma in Rats.

Researchers studied the effects of WS root extract on airway remodeling in a rat model of asthma. The extract showed potential in reducing structural changes and improving airflow limitation, offering new therapeutic options for asthma treatment.

Asthma Withania somnifera
Ali NH et al (2023).
J Pharmacopuncture.
DOI:
10.3831/KPI.2023.26.2.158
PubMed:
37405114

Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques.

Rosa webbiana, a plant used by South Asian herbalists, has potential therapeutic benefits for gastrointestinal and respiratory disorders.

Asthma Rosa webbiana
Ali A and Saqib F (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116696
PubMed:
37315649

The Efficacy of an Oral Formulation of Glycyrrhiza glabra, Viola odorata, and Operculina turpethum as an Add-on Therapy for Mild-to-moderate Childhood Asthma: A Randomized Placebo-Controlled Clinical Trial.

This study tested a new oral tablet for children with mild-to-moderate asthma. It assessed how well it reduced symptoms and could potentially be used as an additional treatment.

Asthma Viola odorata
Rabbani F et al (2023).
J Res Pharm Pract.
DOI:
10.4103/jrpp.jrpp_77_22
PubMed:
37304220

Pinellia ternata (Thunb.) Breit. attenuates the allergic airway inflammation of cold asthma via inhibiting the activation of TLR4-medicated NF-kB and NLRP3 signaling pathway.

Pinellia ternata is effective against allergic airway inflammation, particularly in cold asthma, but its active ingredients and mechanism of action are still unclear.

AsthmaImmunology Pinellia ternata
Tao X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116720
PubMed:
37268256

Targeting calcium signaling by inositol trisphosphate receptors: A novel mechanism for the anti-asthmatic effects of Houttuynia cordata.

Houttuynia cordata, a traditional Chinese herb, may help treat asthma by modulating intracellular calcium signaling and reducing airway remodeling.

Asthma Houttuynia cordata
Huang AS et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114935
PubMed:
37245337

Adenophora Stricta Root Extract Alleviates Airway Inflammation in Mice with Ovalbumin-Induced Allergic Asthma.

The study found that the root extract from Miq., a traditional herb, can reduce inflammation and alleviate symptoms of allergic asthma. It also inhibits the production of proinflammatory mediators by LPS in macrophages. This suggests that Miq. root could be a useful herb for managing airway inflammation in allergic asthma.

AsthmaImmunology Adenophora stricta
Jung CJ et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12040922
PubMed:
37107297
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