Chemotherapy drugs like cisplatin, gemcitabine, and pemetrexed boost immune checkpoint inhibitor efficacy in lung cancer, but low response rates and side effects hinder widespread use.
Piperine, from black and long pepper, shows promise as an anticancer agent for colorectal cancer. Further research needed to understand its molecular mechanisms for potential use in treatment.
Summary: Mangiferin from Mangifera indica has immunomodulatory effects, potential for treating rheumatoid arthritis and cancer by blocking NF-κB, regulating various pathways, activating macrophages, and having proapoptotic effects. Its precise mechanisms are still unknown.$total synthesis screened in vitro & in vivo.
Triptonide from Tripterygium wilfordii is a potent anti-ovarian cancer agent, inducing apoptosis and autophagy through the p38/p53 pathway. It has better efficacy than platinum agents, offering a promising new treatment option.
Lebanese scientists studied how cannabis extracts from Cannabis sativa can help treat arthritis, diabetes, and cancer. Knowing this can help us find new natural remedies for these illnesses.
Phytochemicals from plants like celastrol and resveratrol can target autophagy and ER stress to induce cancer cell death. Understanding how different phytochemicals interact with these processes can help develop new anticancer drugs. However, more research is needed for clinical applications.
Study shows Cynodon dactylon phytochemicals target key genes in EOC pathways. Beta-Sitosterol binds strongly to MAPK3 and PARP1, offering potential for new EOC therapies.
Study investigated how gut microbiota metabolizes flavonoids in Scutellaria barbata, elucidating potential anti-tumor effects. Results inform future studies optimizing cancer treatment with SBD.