Cancer Studies

Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways.

AM-A from Koidz induces unique cell death in breast cancer cells through specific pathways, showing potential as a lead compound for therapeutic development.

Li JR et al (2024).
J Asian Nat Prod Res.
PubMed:
38958645

Sesquilignans PD from Zanthoxylum nitidum var. tomentosum exerts antitumor effects via the ROS/MAPK pathway in liver cancer cells.

Scientists tested the compound sesquilignans on liver cancer cells. It significantly inhibited cell growth, induced cell death processes, and activated specific cell signaling pathways. This study demonstrates sesquilignans' potential as an anticancer agent through multiple mechanisms.

Fan CW et al (2024).
J Asian Nat Prod Res.
PubMed:
38958633

Nanospheres for curcumin delivery as a precision nanomedicine in cancer therapy.

Curcumin, a compound in turmeric, shows promise as a potent anticancer agent. Nanospheres provide an effective delivery method for curcumin, improving targeting and efficacy in cancer treatment, with minimal side effects.

Mahjoubin-Tehran M et al (2024).
J Biomater Sci Polym Ed.
PubMed:
38958210

Comparison of Anticancer, Antioxidant, Enzyme Inhibitory Effects and Phytochemical Contents between Edible Lettuce (Lactuca sativa) and A New Wild Species (Lactuca anatolica).

New species of Lactuca (L. anatolica) showed stronger antioxidant properties compared to L. sativa (LS). Both inhibited cancer cell growth and induced apoptosis, suggesting pharmacological potential for further research.

Erdogan MK et al (2024).
Chem Biodivers.
PubMed:
38958194

Moringa oleifera seed methanol extract with consolidated antimicrobial, antioxidant, anti-inflammatory, and anticancer activities.

Moringa seed extract has potent anticancer, anti-inflammatory, antioxidant, and antibacterial properties. It induces apoptosis, cell cycle arrest, and upregulates tumor-suppressing proteins while being safe for normal cells. It shows promise for developing selective cancer treatment drugs.

El-Fakharany EM et al (2024).
J Food Sci.
PubMed:
38955793

Cytotoxicity of Physalis minima Linn (Solanaceae) fruit against HCT116 and HT29 colorectal cancer cell lines.

Researchers studied the fruit of for potential cancer-fighting properties. Extracts showed cytotoxic effects on colorectal cancer cells, inducing programmed cell death. Identified 71 metabolites with anticancer properties. This study supports the medicinal potential of fruit extracts for cancer treatment.

Ng WL et al (2024).
Nat Prod Res.
PubMed:
38953123

Plant-derived extracellular nanovesicles: a promising biomedical approach for effective targeting of triple negative breast cancer cells.

Plant-derived extracellular nanovesicles (CLENs) inhibit TNBC cell growth and migration by targeting PI3K/AKT and MAPK/ERK pathways. Promising natural anti-cancer agents for TNBC treatment.

Cui L et al (2024).
Front Bioeng Biotechnol.
PubMed:
38952670

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression.

AC medicinal plants have promising effects on colon cancer therapy due to their impact on gut microbiome and bile acid metabolism. Understanding their mechanisms can lead to improved treatment strategies for digestive tract tumors.

Wang X et al (2024).
Front Microbiol.
PubMed:
38952445