Cancer Studies

Evaluation of in vitro anti-cancer potential and apoptotic profile of ethanolic plant extract of Wrightia tinctoria against oral cancer cell line.

The plant () has been used in traditional medicine for years. Many powerful phytochemicals have been isolated from it, making it valuable for modern medicine. It is cheap and native to India.

Thiagarajan MK et al (2024).
J Oral Maxillofac Pathol.
PubMed:
39157850

Main chemical constituents and mechanism of anti-tumor action of Solanum nigrum L.

Research on Solanum nigrum L. shows it has potential anti-tumor effects due to its various bioactive components. Consider using SNL in clinical applications for its therapeutic benefits.

Zhao ZD et al (2024).
Cancer Med.
PubMed:
39155844

Assessment of the anticancer potential of certain phenolic and flavonoid components in ginger capsules using colorectal cancer cell lines coupled with quantitative analysis.

Researchers found that ginger extract had strong anticancer effects on colorectal cancer cells, with high levels of quercetin. This suggests potential for novel and more effective CRC treatments using ginger supplements.

Al Azzam KM et al (2024).
Biomed Chromatogr.
PubMed:
39152776

Plumbagin's Antiproliferative Mechanism in Human Cancer Cells: A Copper-Dependent Cytotoxic Approach.

Plumbagin from Plumbago zeylanica inhibits tumor growth by targeting copper-dependent apoptosis in pancreatic cancer cells. Plumbagin prevents copper efflux, induces ROS production, and suppresses specific genes, suggesting its potential as a cancer treatment.

El Oirdi M et al (2024).
Chem Biol Drug Des.
PubMed:
39147940

Photodynamic therapy with curcumin and near-infrared radiation as an antitumor strategy to glioblastoma cells.

Researchers found that combining curcumin and near-infrared radiation in photodynamic therapy effectively reduces cell proliferation in glioblastoma cells, without harming healthy cells. This promising approach may lead to improved treatment outcomes for this aggressive brain cancer.

Marinho MAG et al (2024).
Toxicol In Vitro.
PubMed:
39142446

High throughput virtual screening and validation of Plant-Based EGFR L858R kinase inhibitors against Non-Small cell lung Cancer: An integrated approach Utilizing GC-MS, network Pharmacology, Docking, and molecular dynamics.

Researchers identified potential inhibitors from Dehydrocostus lactone and Mokkolactone for EGFR L858R mutant lung cancer. These compounds showed anti-proliferative activity and stable binding in molecular simulations. Further in vivo studies are needed for efficacy assessment.

Gao K et al (2024).
Saudi Pharm J.
PubMed:
39139718

Rhus coriaria induces autophagic and apoptotic cell death in pancreatic cancer cells.

Ethanol extract (RCE) inhibits pancreatic cancer cell growth by inducing cell cycle arrest, autophagy, and apoptosis via AKT/mTOR pathway inhibition. Promising potential for anti-cancer treatment.

El Mahi Y et al (2024).
Front Pharmacol.
PubMed:
39139643

Hippophae Rhamnoides-derived Phytomedicine Nano-System Modulates Bax/Fas Pathways to Reduce Proliferation in Triple-Negative Breast Cancer.

Innovative phyto-nanomedicine with sea buckthorn polyphenols and metformin inhibits triple-negative breast cancer cells and induces regulated cell death. Promising potential for effective and less genotoxic TNBC therapy.

Farheen J et al (2024).
Adv Healthc Mater.
PubMed:
39132863