Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells.

Researchers designed micro/nanoparticles using chitosan to encapsulate a yarrow extract with anticancer properties. Spray-drying microparticles showed high encapsulation efficiency and effective release of phenolic compounds, making them a promising vehicle for delivering potential cancer-fighting agents to the colon.

Siles-Sánchez MLN et al (2024).

Drug Deliv.

DOI:

10.1080/10717544.2024.2372285

PubMed:

38952133

In Vitro Studies of Pumpkin (Cucurbita moschata var. Kashi Harit) Seed Protein Fraction(s) to Evaluate Anticancer and Antidiabetic Properties.

Pumpkin seed proteins have potential anticancer and antidiabetic properties. Extracts showed cytotoxic effects on cancer cells and improved insulin secretion in pancreas cells. Promising for cancer and diabetes management.

Vinayashree S et al (2024).

Plant Foods Hum Nutr.

DOI:

10.1007/s11130-024-01205-7

PubMed:

38951376

Inducing Effect of Corylus avellana on Cytotoxic Activity in Lung and Breast Cancer Cells via Apoptosis.

Hazelnut leaf extracts showed anticancer effects on lung and breast cancer cells, inducing apoptosis and inhibiting cell migration. Methanol extract was more effective, with potential for new cancer treatment methods.

Çebi A et al (2024).

Plant Foods Hum Nutr.

DOI:

10.1007/s11130-024-01198-3

PubMed:

38949744

Atractylenolide II combined with Interferon-γ synergistically ameliorates colorectal cancer progression in vivo and in vitro by blocking the NF-kB p65/PD-L1 pathway.

Koidz herbal medicine combined with IFN-γ inhibits CRC progression by regulating NF-kB p65/PD-L1 pathway. Effective against CRC cells and xenograft tumors in mice, shows potential for tumor immunotherapy.

Wu Y et al (2024).

J Cancer.

DOI:

10.7150/jca.96647

PubMed:

38947390

Tetrastigma hemsleyanum polysaccharide combined with doxorubicin promote ferroptosis and immune function in triple-negative breast cancer.

THP from Tetrastigma hemsleyanum induces ferroptosis in TNBC cells, enhancing sensitivity to DOX. It improves tumor microenvironment, immune function, and organ toxicity caused by DOX, presenting a potential treatment strategy for TNBC.

Shang Y et al (2024).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2024.133424

PubMed:

38945330

Association of genetic variants in soy isoflavones metabolism-related genes with decreased lung cancer risk.

Xie D et al (2024).

Gene.

DOI:

10.1016/j.gene.2024.148732

PubMed:

38945312

Evidence of Urtica dioica Agglutinin's Antiproliferative and Anti-migratory Potentials on the Hyaluronic Acid-Overexpressing Prostate Cancer Cells.

Plant lectin agglutinin may inhibit tumor progression by targeting hyaluronic acid in prostate cancer cells. It competes with hyaluronic acid for CD44 binding, reducing cell viability and migration. This potential treatment could disrupt the CD44-HA pathway in cancer cells.

Heydari M et al (2024).

Planta Med.

DOI:

10.1055/a-2324-2250

PubMed:

38942031

Licochalcone D exhibits cytotoxicity in breast cancer cells and enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis through upregulation of death receptor 5.

Licochalcone D (LCD) from Glycyrrhiza uralensis Fisch inhibits breast cancer growth, induces DNA damage, and potentiates TRAIL-induced apoptosis via JNK/p38 MAPK-CHOP pathway. Promising natural anticancer agent.

Zhang Y et al (2024).

J Biochem Mol Toxicol.

DOI:

10.1002/jbt.23757

PubMed:

38937960