Cancer Studies

Thymol as adjuvant in oncology: molecular mechanisms, therapeutic potentials, and prospects for integration in cancer management.

Thymol from thyme shows promise in cancer treatment, inducing cell death and inhibiting metastasis. It enhances the efficacy of 5-fluorouracil in colorectal cancer. Further trials needed.

Herrera-Bravo J et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
38847831

Essential oils with anti-breast cancer activities from Aralia chinensis L. (roots, stems, and leaves) via gas chromatography-mass spectrometry analyses and molecular docking.

L. identified as potential natural medicine for breast cancer treatment due to its antitumor properties. Essential oils target key factors in cancer cells, showing promise for future therapy. Worth further investigation in the lab.

Xue J et al (2024).
Nat Prod Res.
PubMed:
38847180

Network pharmacology prediction and experiment validation of anti-liver cancer activity of Curcumae Rhizoma and Hedyotis diffusa Willd.

Study found CR-HDW has potential anti-liver cancer properties with specific mechanisms. Relevant for identifying potential new treatments for liver cancer.

Tie S et al (2024).
Ann Med Surg (Lond).
PubMed:
38846818

Amentoflavone reverses epithelial-mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis.

Amentoflavone from Selaginella doederleinii reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting core genes and blocking the p53 signaling pathway, leading to reduced cell migration, invasion, and apoptosis. Important for potential cancer treatment strategies.

Jian HY et al (2024).
J Cell Mol Med.
PubMed:
38842135

Mechanistic prediction and validation of Brevilin A Therapeutic effects in Lung Cancer.

This study investigates Brevilin A, a component of Centipeda minima, in treating lung cancer using network pharmacology. Understanding its mechanisms could lead to promising new therapies.

Wang R et al (2024).
BMC Complement Med Ther.
PubMed:
38840248

Gene expression and anticancer evaluation of Kigelia africana (Lam.) Benth. Extracts using MDA-MB-231 and MCF-7 cell lines.

Scientists studied the potential anticancer effects of Kigelia Africana extracts on breast cancer cells. Results show promising anti-proliferative activity, suggesting the plant may have therapeutic potential for cancer treatment. Further research is needed to identify specific active compounds.

Kalsoom A et al (2024).
PLoS One.
PubMed:
38837975

Semisynthesis and antitumor activity of endertiin B and related triterpenoids from Ganoderma lucidum.

Scientists synthesized triterpenoids from a fungus for potential cancer treatment. Endertiin B showed strong anti-tumor activity by blocking cell cycle and inducing apoptosis. Relevant for cancer drug development.

Liu Y et al (2024).
Org Biomol Chem.
PubMed:
38832762

The mechanism of polyphyllin in the treatment of gastric cancer was verified based on network pharmacology and experimental validation.

Researchers predicted targets and mechanisms of Polyphyllin for treating gastric cancer using Paris polyphylla rhizomes. Important for understanding traditional Chinese medicine and developing new GC treatments.

Lu D et al (2024).
Heliyon.
PubMed:
38831826