Cancer Studies

In Vitro Inhibition of Colorectal Cancer Gene Targets by Withania somnifera L. Methanolic Extracts: A Focus on Specific Genome Regulation.

"We studied the effects of L. (WS) plant extracts on colon cancer cells, finding potential as anticancer agents. Further research is needed to validate these findings for clinical use."

CancerGastroenterologyGenetics Withania somnifera
Macharia JM et al (2024).
Nutrients.
DOI:
10.3390/nu16081140
PubMed:
38674831

Fluorescence-Guided Laparoscopy after Oral Hypericin Administration for Staging of Locally Advanced Gastric Cancer-A Pilot Study.

Plant-derived hypericin was not detectable in peritoneal tissue, making fluorescence-guided laparoscopy (FGL) ineffective in detecting peritoneal metastasis in gastric cancer staging. More research needed to optimize hypericin concentrations for FGL effectiveness.

CancerGastroenterology Hypericum perforatum
Yurttas C et al (2024).
J Clin Med.
DOI:
10.3390/jcm13082422
PubMed:
38673695

Patients with Advanced or Metastasised Non-Small-Cell Lung Cancer with Viscum album L. Therapy in Addition to PD-1/PD-L1 Blockade: A Real-World Data Study.

Adding VA to PD-1/PD-L1 inhibitors in NSCLC patients improves overall survival. 56% reduced risk of death compared to PD-1/PD-L1 alone, especially in PD-L1-positive tumors. Need more trials for confirmation.

Cancer Viscum album
Schad F et al (2024).
Cancers (Basel).
DOI:
10.3390/cancers16081609
PubMed:
38672690

The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway.

Curcumin, from turmeric, has anti-cancer properties by inhibiting the PI3K/Akt pathway. Promising for various cancers.

Cancer Curcuma longa
Zoi V et al (2024).
Cancers (Basel).
DOI:
10.3390/cancers16081554
PubMed:
38672636

Correction: Abbas et al. Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, and Toxicity Assessment of Tribulus terrestris-In Vitro and In Vivo Studies. Antioxidants 2022, 11, 1160.

They conducted a study on the effects of carbon nanotubes on cellular health. Important for understanding potential risks of nanomaterial exposure in lab settings.

CancerImmunology Tribulus terrestris
Abbas MW et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13040471
PubMed:
38671949

Selenochemical modification of low molecular weight polysaccharides from Grifola frondosa and the mechanism of their inhibitory effects on gastric cancer cells.

Selenium enhances LMW-GFP polysaccharide's antitumor effect by binding to it, significantly improving in vitro activity against BGC-823 and MFC cells, suggesting potential for cancer treatment and selenium supplementation development.

CancerGastroenterology Grifola frondosa
Huo Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.131812
PubMed:
38670197

Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation.

Polyphyllin I (PPI), from Paris polyphylla, exhibits strong cytotoxicity on AML cells via ferroptosis induction. PPI targets PI3K/SREBP-1/SCD1 axis and triggers lipid peroxidation, with potential to enhance erastin-induced ferroptosis. PPI is a PI3K inhibitor, inhibits tumor progression, and prolongs survival in mice.

Cancer Paris polyphylla
Zhou X et al (2024).
J Nat Med.
DOI:
10.1007/s11418-024-01811-4
PubMed:
38668832

From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches.

Researchers investigated Saudi Arabian flora compounds in treating ovarian cancer, identifying key genes and pathways. Compounds like ascorbic acid and hispidulin showed promising interactions with AKT1 and VEGFA proteins, suggesting potential for future anti-cancer treatments.

Cancer Carissa carandasCarissa spinarumCyperus rotundus
Alblihy A et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1345415
PubMed:
38666020
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