Cancer Studies

Alkaloids from Zanthoxylum nitidum and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway.

Ten alkaloids isolated from showed significant antiproliferative effects against A549 cancer cells. Compound induced cell cycle arrest and inhibited cell migration through the EGFR/AKT/mTOR signaling pathway. Potential lead antiproliferative compound in cancer cells.

CancerPhytochemistry Zanthoxylum nitidum
Wang FF et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2347463
PubMed:
38684029

The Potential Role of Phytochemicals of Juniperus procera in the Treatment of Ovarian Cancer and the Inhibition of Human Topoisomerase II Alpha Activity.

Fruit and leaf extracts from medicinal plants show promise as potential anticancer drugs, inhibiting ovarian cancer cells and targeting key enzymes, offering new avenues for drug development.

CancerEndocrinology Juniperus procera
Al-Zahrani AA et al (2024).
Bioinform Biol Insights.
DOI:
10.1177/11779322241248904
PubMed:
38681095

Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats.

Study found Mill. plant has anti-cancer properties in breast cancer model. Potential for new cancer treatment.

Cancer Ambrosia arborescens
Silva-Correa CR et al (2024).
Vet World.
DOI:
10.14202/vetworld.2024.700-704
PubMed:
38680140

Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization.

Ganoderic acid D from Ganoderma lucidum may reverse gemcitabine resistance in triple-negative breast cancer, potentially expanding treatment options for patients.

Cancer Ganoderma lucidum
Luo B et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155675
PubMed:
38678954

Antitumor mechanisms and future clinical applications of the natural product triptolide.

Triptolide (TPL) from a Chinese herb shows promise for fighting cancer, but its mechanism is unclear and its toxicity limits use. Research is underway to better understand how TPL works and improve its clinical application for treating tumors.

Cancer Tripterygium wilfordii
Bao S et al (2024).
Cancer Cell Int.
DOI:
10.1186/s12935-024-03336-y
PubMed:
38678240

Structural characterization of the polysaccharide from the black crystal region of Inonotus obliquus and its effect on AsPC-1 and SW1990 pancreatic cancer cell apoptosis.

IOP1-1, a polysaccharide from Inonotus obliquus, inhibits pancreatic cancer cell growth and induces apoptosis through multiple pathways. Potential adjuvant for cancer treatment.

Cancer Inonotus obliquus
Ding M et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.131891
PubMed:
38677687

Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification.

Silibinin, a compound from milk thistle seeds, has anti-tumor effects in adenoid cystic carcinoma cells and mice. It inhibits cell growth, induces apoptosis, and alters protein expression related to cancer pathways. Potential key targets include CASP3, SRC, and JAK. Use of silibinin in cancer treatment is supported.

Cancer Silybum marianum
Li P et al (2024).
Molecules.
DOI:
10.3390/molecules29081901
PubMed:
38675723

Anti-Tumor Effects and Toxicity Reduction Mechanisms of Prunella vulgaris: A Comprehensive Review.

Researchers studied the way () fights digestive tumors and decreases toxicity. This information may help develop better treatments for these types of cancer.

Cancer Prunella vulgaris
Ning N et al (2024).
Molecules.
DOI:
10.3390/molecules29081843
PubMed:
38675663
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