Cancer Studies

Liensinine diperchlorate and artemisitene synergistically attenuate breast cancer progression through suppressing PI3K-AKT signaling and their efficiency in breast cancer patient-derived organoids.

LIN and ATT, compounds from lotus and Artemisia, synergistically inhibit breast cancer cell growth and invasion by enhancing apoptosis and suppressing PI3K-AKT signaling. Promising potential for BC therapy.

Lin X et al (2024).
Biomed Pharmacother.
PubMed:
38861856

Alpha-Hederin induces incomplete autophagic injury in non-small cell lung cancer by interfering with the lysosomal acidification.

Alpha-Hederin from ivy or black seed plants shows promise in treating non-small cell lung cancer by inhibiting mTOR, disrupting autophagy, and causing autophagic damage.

Jin F et al (2024).
Sci Rep.
PubMed:
38858422

HPLC, NMR Based Characterization, Antioxidant and Anticancer Activities of Chemical Constituents from Therapeutically Active Fungal Endophytes.

Endophytic fungi from medicinal plants produce bioactive compounds with potential for drug development. Aspergillus flavus showed antibiofilm and antioxidant activity, with compounds identified for anti-cancer properties. Further research is warranted on these promising findings.

Shah WH et al (2024).
J Microbiol Biotechnol.
PubMed:
38858094

Can Chinese herbal medicine offer feasible solutions for newly diagnosed esophageal cancer patients with malnutrition? a multi-institutional real-world study.

Study on CHM use in EC patients with malnutrition in Taiwan. CHM commonly used but long-term impact unclear. Important for patient prognosis and treatment decisions.

Lu YC et al (2024).
Front Pharmacol.
PubMed:
38855746

Potential anti-liver cancer targets and mechanisms of kaempferitrin based on network pharmacology, molecular docking and experimental verification.

Kaempferitrin in Chenopodium ambrosioides fights liver cancer by targeting specific pathways, verified in mice models. Important for developing treatments for liver cancer.

Zhou S et al (2024).
Comput Biol Med.
PubMed:
38850960

Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics.

Researchers created Centella asiatica-derived nanovesicles (ADNVs) with anticancer properties through a simple process. ADNVs target diseases like cancer, show internalization in HepG2 cells, and impact metabolic pathways, suggesting their potential as effective anticancer agents.

Huang J et al (2024).
Biomed Pharmacother.
PubMed:
38850651

Phenolic Contents, Antioxidant Activities, LCMS Profiles of Mespilus germanica Leaf Extract and Effects on mRNA Transcription Levels of Apoptotic, Autophagic, and Necrotic Genes in MCF7 and A549 Cancer Cell Lines.

Scientists studied the impact of Mespilus germanica leaf extract on cancer cells and healthy cells. Results show potential for cancer treatment without harming healthy cells.

Görmez G et al (2024).
Cell Biochem Biophys.
PubMed:
38850406