Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2.

Researchers studied the traditional use of L. japonicus in treating estrogen-related gynecological disorders. Understanding its mechanism could lead to new treatments for conditions like PCOS.

Shi XK et al (2024).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2024.118279

PubMed:

38705425

Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4.

Angelica sinensis polysaccharide (ASP) reverses cisplatin resistance in ovarian cancer cells by suppressing GPX4 expression. ASP in combination with cisplatin shows promise in overcoming drug resistance.

Guo W et al (2024).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2024.116680

PubMed:

38703506

Macromolecules with predominant β-pleated sheet proteins in extracellular vesicles released from Raphanus sativus L. var. caudatus Alef microgreens induce DNA damage-mediated apoptosis in HCT116 colon cancer cells.

Kaimuangpak K et al (2024).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2024.132001

PubMed:

38702007

Salvia miltiorrhiza inhibited lung cancer through aerobic glycolysis suppression.

Bai J et al (2024).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2024.118281

PubMed:

38701934

[Syntheses and Structure-Activity Relationship Studies of Antitumor Bicyclic Hexapeptide RA-VII Analogues].

Scientists synthesized modified analogues of RA-VII peptides from Rubia cordifolia roots, testing them against various cancer cell lines. They found that certain modifications were crucial for potent cytotoxic activity, highlighting potential new treatment strategies.

Hitotsuyanagi Y et al (2024).

Yakugaku Zasshi.

DOI:

10.1248/yakushi.23-00208

PubMed:

38692932

Pharmacological Properties of White Mulberry (Morus alba L.) Leaves: Suppressing Migratory and Invasive Activities Against A549 Lung Cancer Cells.

Srisomsap C et al (2024).

Plant Foods Hum Nutr.

DOI:

10.1007/s11130-024-01184-9

PubMed:

38691297

Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation.

Shaban NZ et al (2024).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2024.116638

PubMed:

38688169

Molecular mechanisms of Asparagus racemosus willd. and Withania somnifera (L.) Dunal as chemotherapeutic adjuvants for breast cancer treatment.

Prasad K et al (2024).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2024.118261

PubMed:

38685363