Cancer Studies

Antineoplastic Drug Synergy of Artesunate with Navitoclax in Models of High-Grade Serous Ovarian Cancer.

Researchers found artesunate, a drug for severe malaria, enhances cell death in ovarian cancer when combined with navitoclax. This combo shows promising antineoplastic effects in both cell and animal models, hinting at a potential new treatment option for ovarian cancer.

McCorkle JR et al (2024).
Cancers (Basel).
PubMed:
38610999

Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells.

BOL from Brucea javanica inhibits breast cancer cell growth by targeting CDK2/4/6 and activating ERK. Potential anti-breast cancer treatment option.

Sun L et al (2024).
Chem Biol Interact.
PubMed:
38608999

Corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis.

Study on Exo and their impact on prostate cancer growth and spread. Understanding their role could lead to new treatments or prevention strategies for the disease.

Jin M et al (2024).
Int Immunopharmacol.
PubMed:
38608471

Active substance and mechanisms of Actinidia chinensis Planch for the treatment of breast cancer was explored based on network pharmacology and in silico study.

Researchers used network pharmacology and molecular dynamics to study ACP for breast cancer treatment. Identified key genes and pathways, providing theoretical basis for further research and potential clinical applications.

Xu Y et al (2024).
Medicine (Baltimore).
PubMed:
38608062

Huang Lian Jie Du Decoction enhances the anti-tumor efficacy of immune checkpoint inhibitors by activating TLR7/8 signalling in melanoma.

Researchers studied how the traditional Chinese medicine HLJD can enhance the effectiveness of ICIs in melanoma treatment. Understanding this may improve cancer immunotherapy outcomes by overcoming drug resistance.

Liu S et al (2024).
BMC Complement Med Ther.
PubMed:
38605368

Anticancer, antioxidant, and antibacterial activity of chemically fingerprinted extract from Cyclamen persicum Mill.

Researchers studied the medicinal properties of Cyclamen persicum (C. persicum) in Palestine. Extract showed weak antibacterial effects but strong anti-cancer and antioxidant properties due to high phenolic and flavonoid content. Important for potential pharmaceutical use.

Al-Rimawi F et al (2024).
Sci Rep.
PubMed:
38605145

The anti-colorectal cancer effect and metabolites of Agrimonia pilosa Ledeb.

Scientists isolated secondary metabolites from Agrimonia pilosa for potential anti-colorectal cancer properties. Traditional medicine in Asia commonly uses it for enteritis and diarrhea treatment.

Wang L et al (2024).
J Ethnopharmacol.
PubMed:
38604512

Identification of Flavonoids, Antioxidant and Antiproliferative Activity of Aqueous Infusions of Calendula officinalis L., Chelidonium majus L., Teucrium chamaedrys L. and Alchemilla vulgaris L.

Study explores biopotential of medicinal herb infusions to meet increasing demand due to global changes. Important for future healthcare needs in face of climate crisis and COVID-19.

Bilušić T, Šola I and Čikeš Čulić V (2024).
Food Technol Biotechnol.
PubMed:
38601959