Discovery of potential epidermal growth factor receptor inhibitors from black pepper for the treatment of lung cancer: an in-silico approach.

Scientists tested 37 Piper nigrum compounds for lung cancer treatment. Clarkeinol A showed strongest binding to EGFR, with potential as a specific inhibitor with fewer side effects. Further research is warranted.

Elekofehinti OO et al (2024).

In Silico Pharmacol.

DOI:

10.1007/s40203-024-00197-1

PubMed:

38601803

[Biological mechanisms of Oxalis corniculata regulating human prostate cancer PC-3 cells: An investigation based on the NF-κB pathway].

Study tested Oxalis corniculata on PC-3 cells to understand its impact on prostate cancer. Findings may inform potential natural treatments for the disease.

Zhang GW et al (2023).

Zhonghua Nan Ke Xue.

PubMed:

38597700

[Single extract of Forsythia Suspense versus the prepared drug in pieces: comparison of their anti-inflammatory, antitumor and antibacterial effects in zebrafish].

Researchers evaluated the effects of Forsythia Suspense extract on inflammation, tumors, and bacteria. Results can guide potential use in medicine.

Guo X et al (2024).

Nan Fang Yi Ke Da Xue Xue Bao.

DOI:

10.12122/j.issn.1673-4254.2024.03.22

PubMed:

38597452

Phytochemical identification and in silico elucidation of interactions of bioactive compounds from Citrullus lanatus with androgen receptor towards prostate cancer treatment.

Study investigated fruit compounds as potential AR inhibitors for prostate cancer therapy. Naringenin showed promising results in binding to AR. Further research on these compounds, especially naringenin, may lead to new drug development.

Demian MD et al (2024).

In Silico Pharmacol.

DOI:

10.1007/s40203-024-00193-5

PubMed:

38596366

Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis.

Arctigenin from Arctium lappa plant protects neurons from drug-induced neurotoxicity by preventing ferroptosis through activating SLC7A11-cystine-cysteine axis. Potential novel agent for neuroprotection.

Li Z et al (2024).

Biochem Biophys Res Commun.

DOI:

10.1016/j.bbrc.2024.149895

PubMed:

38593620

Piperlongumine and its derivatives against cancer: A recent update and future prospective.

Researchers studied Piperlongumine (PL) derivatives for anticancer activity. Modifications can improve potency, solubility, and bioavailability. Important for developing less toxic and cost-effective anticancer drugs.

Swain SS and Sahoo SK (2024).

Arch Pharm (Weinheim).

DOI:

10.1002/ardp.202300768

PubMed:

38593312

KLF4 suppresses anticancer effects of brusatol via transcriptional upregulating NCK2 expression in melanoma.

Li X et al (2024).

Biochem Pharmacol.

DOI:

10.1016/j.bcp.2024.116197

PubMed:

38583810

Biogenic Zinc Oxide Nanoparticles synthesized from Tinospora Cordifolia induce oxidative stress, mitochondrial damage and apoptosis in Colorectal Cancer.

Berehu HM and Patnaik S (2024).

Nanotheranostics.

DOI:

10.7150/ntno.84995

PubMed:

38577319