GeoBotanical: Cancer Studies

377.

The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro.

Scientists studied how mesenchymal stem cells (MSCs) interact with cancer cells in the tumor microenvironment (TME) using natural plant extracts. MSC secretome combined with extracts inhibited cancer cell viability and migration, showing potential for cancer treatment.

Cancer Petiveria alliacea

Ramirez JA et al (2024).; Histochem Cell Biol.
DOI:: 10.1007/s00418-024-02265-1
PubMed:: 38402366

378.

Exploring the Potential of Essential Oil from Plectranthus amboinicus Leaves against Breast Cancer: In vitro and In silico Analysis.

Essential oil from Plectranthus amboinicus showed promising antiproliferative activity against breast cancer cell lines. Molecule 4BHP may be a potential candidate for aromatase inhibition, but further research is needed for safety and efficacy. Novel drug delivery systems could enhance breast cancer treatment.

Cancer Phytochemistry Plectranthus amboinicus

Gupta K et al (2024).; Med Oncol.
DOI:: 10.1007/s12032-024-02325-5
PubMed:: 38400892

379.

Calotropis procera extract inhibits prostate cancer through regulation of autophagy.

Calotropis procera leaf extract inhibits prostate cancer cell viability by regulating autophagy and ROS levels, making it a potential alternative therapy with fewer side effects.

Cancer Calotropis procera

Singh P et al (2024).; J Cell Mol Med.
DOI:: 10.1111/jcmm.18050
PubMed:: 38400579

380.

Arnicolide C Suppresses Tumor Progression by Targeting 14-3-3θ in Breast Cancer.

Arnicolide C has promising antitumor effects in breast cancer by inhibiting cell proliferation, inducing apoptosis, and targeting 14-3-3θ protein. Further research needed on specific mechanism.

Cancer Centipeda minima

Liu Z et al (2024).; Pharmaceuticals (Basel).
DOI:: 10.3390/ph17020224
PubMed:: 38399439

381.

Synergistic Anticancer Activity of Plumbagin and Xanthohumol Combination on Pancreatic Cancer Models.

Plumbagin and xanthohumol combo shows strong anticancer activity in pancreatic cancer models by affecting BCL2 levels, leading to increased survival in mice. Potential new treatment option.

Cancer Humulus lupulus

Palanisamy R et al (2024).; Int J Mol Sci.
DOI:: 10.3390/ijms25042340
PubMed:: 38397018

382.

Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling.

Rosemary extract compound carnosic acid inhibits non-small cell lung cancer (NSCLC) cell growth and induces apoptosis by activating the Sestrin-2/LKB1/AMPK pathway, promoting autophagy. Potential novel therapy for NSCLC.

Cancer Rosmarinus officinalis

O'Neill EJ et al (2024).; Int J Mol Sci.
DOI:: 10.3390/ijms25041950
PubMed:: 38396629

383.

Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity.

Inonotus obliquus polysaccharides AcF1 and AcF3 activate tumor-fighting functions in macrophages by triggering immune receptors TLR2 and TLR4, showing promise for cancer immunotherapy.

Cancer Immunology Inonotus obliquus

Wold CW et al (2024).; Commun Biol.
DOI:: 10.1038/s42003-024-05853-y
PubMed:: 38396285

384.

Assessment of the effect of drying on Brassica greens via a multiplex approach based on LC-QTOF-MS/MS, molecular networking, and chemometrics along with their antioxidant and anticancer activities.

Drying methods (lyophilization, vacuum oven, shade drying) of turnip leaves impact phytochemical composition. Lyophilization and shade drying result in higher antioxidant and anticancer activities. Shade drying is cost-effective with similar benefits. Provides foundation for further research on Brassica greens.

Cancer Immunology Brassica rapa

Khalil MNA et al (2024).; Food Res Int.
DOI:: 10.1016/j.foodres.2024.114053
PubMed:: 38395547