Network pharmacology, bioinformatics, and experimental validation to identify the role of Hedyotis diffusa willd against gastric cancer through the activation of the endoplasmic reticulum stress.

Ou L, Li M and Hou Y (2024).

Heliyon.

DOI:

10.1016/j.heliyon.2024.e28833

PubMed:

38576568

Novel bioactive extract from yarrow obtained by the supercritical antisolvent-assisted technique inhibits lipid metabolism in colorectal cancer.

Gómez de Cedrón M et al (2024).

Front Bioeng Biotechnol.

DOI:

10.3389/fbioe.2024.1256190

PubMed:

38576446

Mechanism Research of PZD Inhibiting Lung Cancer Cell Proliferation, Invasion, and Migration Based on Network Pharmacology.

Feng F et al (2024).

Curr Pharm Des.

DOI:

10.2174/0113816128296328240329032332

PubMed:

38571356

Fabrication of bimetallic Ag@ZnO nanocomposite and its anti-cancer activity on cervical cancer via impeding PI3K/AKT/mTOR pathway.

Bimetallic Ag@ZnO NCs synthesized from Crocus sativus extract show promising anti-cancer properties against cervical cancer, outperforming other nanoparticles. Research may lead to improved cancer therapy methods.

Yin Q et al (2024).

J Trace Elem Med Biol.

DOI:

10.1016/j.jtemb.2024.127437

PubMed:

38564977

Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer.

Nanoparticles, specifically Fe nanoparticles made from Mentha spicata extract, show great potential for targeted colon cancer treatment with reduced side effects. Further clinical trials needed.

Nejad FS et al (2024).

Heliyon.

DOI:

10.1016/j.heliyon.2024.e28343

PubMed:

38560153

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling.

23-HBA from P. chinensis inhibits M2 macrophage polarization, decreasing resistance to 5-FU in colorectal cancer. Suppresses IL-10/STAT3/Bcl-2 pathway, enhancing 5-FU efficacy and reducing M2 macrophage presence in tumor tissues.

Fan Z et al (2024).

Cancer Immunol Immunother.

DOI:

10.1007/s00262-024-03662-0

PubMed:

38554148

Establishment of cluster of differentiation 20 immobilized cell membrane chromatography for the screening of active antitumor components in traditional Chinese medicine.

Researchers developed a model to study a small molecule's interaction with CD20 protein in lymphoma cells. Compounds from Schisandra chinensis and Lysionotus pauciflorus were found to target CD20, with potential for improving non-Hodgkin lymphoma treatment.

Ding Y et al (2024).

J Chromatogr A.

DOI:

10.1016/j.chroma.2024.464845

PubMed:

38552371

Network pharmacology and experimental insights into STAT3 inhibition by novel isoxazole derivatives of piperic acid in triple negative breast cancer.

Researchers synthesized isoxazole derivatives from piperic acid to inhibit STAT3 in breast cancer cells. Studies show potential as effective anticancer agents, offering promise for developing new chemotherapy drugs.

Yatoo GN et al (2024).

Fitoterapia.

DOI:

10.1016/j.fitote.2024.105927

PubMed:

38548028