Cancer Studies

Integrating Network Pharmacology and In Vitro Experiments for Assessing the Anti-Tumor Effects of Phyllanthus Urinaria L Anti-neoplastic Decoction in Hepatocellular Carcinoma.

Chinese herb formulas with "yiqi jianpi jiedu huayu" can effectively treat hepatocellular carcinoma, but the mechanisms are unknown. Understanding this can improve HCC treatment with traditional Chinese medicine.

Wei C et al (2024).
Altern Ther Health Med.
PubMed:
38758152

Evaluating the effects of various ethanolic medicinal plant extracts on metastatic breast cancer proliferation, invasion, and expression of a novel potential drug target; CD82 metastatic suppressor protein, and on in vivo angiogenesis using the ex ovo yolk sac membrane (YSM) assay.

Researchers screened plant extracts for anti-metastatic properties in breast cancer cells by targeting CD82 expression. Results show potential for multi-system treatment to inhibit metastasis and improve patient outcomes.

Loggenberg S, Twilley D and Lall N (2024).
J Cancer Res Clin Oncol.
PubMed:
38753184

Biological activities of fig latex -loaded cellulose acetate/poly(ethylene oxide) nanofiber for potential therapeutics: Anticancer and antioxidant material.

Fig latex encapsulated in CA/PEO nanofiber scaffold effectively targets cancer cells with minimal harm to normal cells, demonstrating promising potential as a safer alternative to traditional chemotherapy.

El Fawal G, Sobhy SE and Hafez EE (2024).
Int J Biol Macromol.
PubMed:
38750845

Ganoderma lucidum spores-derived particulate β-glucan treatment improves antitumor response by regulating myeloid-derived suppressor cells in triple-negative breast cancer.

GPG, a glucan from Ganoderma lucidum, improves immune response in breast cancer. Combining with Gemcitabine reduces tumor burden, alters TME, and inhibits MDSC expansion. GPG reverses immunosuppression induced by chemotherapy.

Bu Y et al (2024).
Int J Biol Macromol.
PubMed:
38749890

Molecular insights into the antioxidant and anticancer properties: A comprehensive analysis through molecular modeling, docking, and dynamics studies.

Researchers evaluated Solanum virginianum seeds for therapeutic compounds. Methanol extract showed highest phenolic & flavonoid content, antioxidant activity, and promising anticancer potential. This study emphasizes the importance of natural compounds in drug discovery.

Banu HS et al (2024).
J Cell Biochem.
PubMed:
38747366

Bioguided Fractionation of Phyllanthus spp.: Unveiling Anticancer Potential through Metabolomic Correlation and ADMETox Insights.

Scientists studied plants from the Phyllanthus genus for potential cancer treatments. They identified bioactive compounds using advanced analytical techniques and found promising results, suggesting the potential for future drug development. This research highlights the importance of natural products in cancer therapy.

Silva FS et al (2024).
Chem Biodivers.
PubMed:
38747034

Identification of Scutebarbatine B metabolites in rats using UHPLC-Q-Orbitrap-MS/MS and exploration of its mechanism of reversal multidrug resistance in breast cancer by network pharmacology and molecular docking studies.

"SBT-B from S. barbata inhibits P-gp, reversing MDR in breast cancer. Identified 18 novel metabolites, mainly through oxidization and acetylation. Targets p27 phosphorylation, p53 signaling, and inhibits P-gp expression. Provides new insight for P-gp inhibitor development."

Zhang H et al (2024).
J Pharm Biomed Anal.
PubMed:
38744199