Cancer Studies

Polyacetylenes from Saposhnikovia divaricata and their anticancer activity.

Researchers isolated 9 polyacetylenes from Saposhnikovia divaricata roots, including 5 new compounds, and determined their structures. Compound 9 showed moderate cytotoxicity against HEPG2 cancer cells.

Sun Y et al (2024).
Fitoterapia.
PubMed:
38431027

Comparative analysis of chemical profiles, antioxidant, antibacterial, and anticancer effects of essential oils of two Thymus species from Montenegro.

Thyme essential oils from Montenegro have antioxidant, antibacterial, and anticancer properties. TVEO had higher cytotoxic effects and tumor-suppressive properties than TSEO, making them potential candidates for cancer treatment.

Preljević K et al (2024).
Fitoterapia.
PubMed:
38428618

Bruceantinol targeting STAT3 exerts promising antitumor effects in in vitro and in vivo osteosarcoma models.

Bruceantinol (BOL) from Brucea javanica inhibits growth and metastasis of osteosarcoma cells by binding to STAT3, showing promise as a therapeutic agent for OS.

Miao J et al (2024).
Mol Carcinog.
PubMed:
38426797

Antioxidant polysaccharide-enriched fractions obtained from olive leaves by ultrasound-assisted extraction with α-amylase inhibition, and antiproliferative activities.

Researchers extracted polysaccharide-rich materials from olive leaves, finding antioxidant, alpha-amylase inhibition, and antiproliferative activities. The extract showed potential for functional food development due to synergistic effects of its compounds.

Elayeb R et al (2024).
3 Biotech.
PubMed:
38425411

Antiproliferative and Antimigratory Activity of Poly-gallic Acid in Cancer Cell Lines.

Scientists modified molecules to create potential cancer treatment with low toxicity. Tested on liver, breast, and prostate cancer cells, showing promise for treatment with good cell compatibility.

Hernandez-Valencia CG et al (2024).
Anticancer Res.
PubMed:
38423672

Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells.

Morindone, a compound from Morinda citrifolia, shows promise as a potential anticancer agent for colorectal cancer with mutated TP53 and KRAS genes, exhibiting anti-proliferative and pro-apoptotic effects through multiple mechanisms.

Chee CW, Mohd Hashim N and Nor Rashid N (2024).
Chem Biol Interact.
PubMed:
38423379

Synthesis of Bimetallic Palladium/Zinc Oxide Nanocomposites Using Crocus sativus and Its Anticancer Activity via the Induction of Apoptosis in Cervical Cancer.

Researchers successfully synthesized bimetallic nanoparticles (CS-Pd/ZnO NCs) using a natural extract, assessing their antioxidant and anti-cancer properties. These nanoparticles showed potential for cervical cancer treatment by inducing cell death and apoptosis.

Feng J et al (2024).
Appl Biochem Biotechnol.
PubMed:
38421572