CBD, found in Cannabis sativa, induces cell death in colorectal cancer cells. It activates the MAPK pathway, leading to apoptosis, paraptosis, and autophagy. This suggests that CBD could be a potential treatment for colorectal cancer.
ATL III, a compound in Atractylodes macrocephala, inhibits migration and invasion of cervical cancer cells by regulating IGF2BP3 through ETV5. This has potential implications for cervical cancer treatment.
A nanoformulation combining Pistacia lentiscus essential oil and 5-Fluorouracil showed improved stability, targeting abilities, and antioxidant properties, resulting in stronger anticancer effects against breast and melanoma cells compared to free compounds. It may be a promising treatment for localized breast cancer and melanoma.
Licochalcone A (LCA), from licorice roots, reduces AML cell viability, induces cell death, inhibits signaling pathways, and enhances effectiveness of venetoclax, indicating potential as AML treatment.
Scoparone (SCO) downregulates PD-L1 expression in breast cancer cells via AKT inhibition and upregulation of MKP-3 expression. SCO could be a potential combinatorial agent for cancer immunotherapy.
Scientists isolated and characterized a trypsin inhibitor from Cajanus cajan leaves. The inhibitor showed high affinity for trypsin and inhibited the activity of secreted serine proteases. It also reduced the growth of melanoma and colon adenocarcinoma cells. This could be a potential drug candidate for chemotherapy.
Scientists made a way to deliver pomegranate extract to breast, colon, and uterus tumors; it improves treatment effectiveness and reduces side effects.
Researchers discovered a potent fungus from roots that can inhibit breast cancer cell growth. The fungus synthesizes bioactive compounds, and several lead compounds were identified as potential anti-cancer agents. This study suggests the fungus could be used to develop new chemotherapy drugs.