Cancer Studies

α-Hederin promotes ferroptosis and reverses cisplatin chemoresistance in non-small cell lung cancer.

Researchers investigated the effects of α-Hederin, a natural compound, on cisplatin resistance in non-small cell lung cancer (NSCLC). Understanding this interaction is crucial for improving chemotherapy outcomes in NSCLC patients.

Han S et al (2024).
Aging (Albany NY).
PubMed:
38244586

Network Pharmacology Analysis and In Vitro Validation of the Active Ingredients and Potential Mechanisms of Gynostemma Pentaphyllum Against Esophageal Cancer.

Researchers investigated the potential anti-esophageal cancer effects of Gynostemma pentaphyllum Thunb. Makino. Understanding its active components and mechanisms can lead to improved treatment options for esophageal cancer.

Guo J et al (2024).
Comb Chem High Throughput Screen.
PubMed:
38243957

Nanotechnological synergy of mangiferin and curcumin in modulating PI3K/Akt/mTOR pathway: a novel front in ovarian cancer precision therapeutics.

Researchers used nanotechnology to enhance the delivery and effectiveness of potential anti-cancer compounds against ovarian cancer. Computational analysis confirmed their affinity with cancer pathway proteins, while liposomal technology improved drug delivery and uptake. This approach has the potential to revolutionize ovarian cancer treatment.

Alharbi HM et al (2024).
Front Pharmacol.
PubMed:
38239204

Possible protective anticancer effect of chloroform fraction of Iraqi Hibiscus tiliaceus L. leaves extract on diethylnitrosamine-induced hepatocarcinogenesis in male rats.

Iraqi chloroform leaf extract was investigated for its ability to protect against DEN-induced hepatocellular carcinoma (HCC) in male Wistar Albino rats. This research is relevant for finding potential treatments for HCC.

Abdul-Azeez ZM and Mutlag SH (2024).
J Complement Integr Med.
PubMed:
38236421

Viscum album (mistletoe) extract for dogs with cancer?

This paper suggests using mistletoe extract as a potential treatment for dogs with cancer. It contains compounds that can inhibit cancer cell growth and stimulate the immune system, improving well-being. Its low side effect profile makes it worth considering.

Klingemann H et al (2024).
Front Vet Sci.
PubMed:
38234984

Embelin: A multifaceted anticancer agent with translational potential in targeting tumor progression and metastasis.

Embelin from Embelia plants inhibits cancer cell growth via multiple mechanisms, making it a promising anticancer agent supported by scientific literature. Consider its potential for your lab's research on cancer treatment.

Kamath AJ et al (2023).
EXCLI J.
PubMed:
38234968

Protective Assessment of Novel (Bncs Formulation) against Brain Tumor.

Researchers investigated the neuroprotective effects of a formulation containing Bacopa monnieri leaves, Nigella sativa, and Curcuma longa rhizome seeds. This formulation may help protect against oxidative stress and cell death induced by diclofenac, a common anti-inflammatory drug.

Mishra A et al (2024).
Recent Pat Anticancer Drug Discov.
PubMed:
38231063

Triptolide inhibits proliferation and invasion of colorectal cancer cells by blocking Nrf2 expression.

Triptolide (TPL) from Tripterygium wilfordii inhibits colorectal cancer (CRC) cell growth and invasion. It promotes cell death and reduces the levels of MMP-2 and MMP-9. The mechanism involves inhibition of Nrf2 signaling.

Wang HF and Zhao ZL (2024).
Chem Biol Drug Des.
PubMed:
38230794