Cancer Studies

Antiproliferative and anti-inflammatory effects of fractionated crude lectins from boiled kidney beans (Phaseolus vulgaris).

Boiled lectins from Japanese red kidney beans (RKB) have anticancer and anti-inflammatory effects. They can be used for medical research and developed as potential chemopreventive and anticancer agents.

CancerImmunology Phaseolus vulgaris
Une S et al (2023).
J Food Sci.
DOI:
10.1111/1750-3841.16847
PubMed:
37983860

Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn.

Researchers used a model to identify four potential EGFR antagonists in Silybum marianum, showing potential for new, efficient, and less toxic cancer treatment.

CancerPhytochemistry Silybum marianum
Zhang X et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115816
PubMed:
37976988

Selective and reliable fluorometric quantitation of anti-cancer drug in real plasma samples using nitrogen-doped carbon dots after MMIPs solid phase microextraction: Monitoring methotrexate plasma level.

Researchers synthesized a fluorescence probe for precise quantitation of methotrexate (MTX). The probe showed a wide detection range, high sensitivity, and selectivity. It was successfully applied for quantification of MTX in rabbit plasma samples, with potential for pharmaceutical applications.

Cancer Annona squamosa
Alanazi AZ et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115862
PubMed:
37976985

Integrating bioinformatics and experimental models to investigate the mechanism of the chelidonine-induced mitotic catastrophe via the AKT/FOXO3/FOXM1 axis in breast cancer cells.

Chelidonine, an ingredient in Chelidonium majus, can trigger mitotic catastrophe in breast cancer (BC) cells. FOXO3 is a potential biomarker for BC prognosis, and chelidonine inhibits BC cell proliferation, induces M phase arrest, and weakens the AKT/FOXO3/FOXM1 axis, making it a promising treatment for BC.

Cancer Chelidonium majus
Li H et al (2023).
Biomol Biomed.
DOI:
10.17305/bb.2023.9665
PubMed:
37976368

Biosynthesis of Artemisia abyssinica Leaf Extract-Mediated Bimetallic ZnO-CuO Nanoparticles: Antioxidant, Anticancer, and Molecular Docking Studies.

A study synthesized plant extract-mediated metal oxide nanoparticles and evaluated their anticancer, antioxidant, and molecular binding efficacy. The biosynthesized nanoparticles showed potential as antioxidant and anticancer drug candidates, particularly for breast cancer. Cytotoxicity tests are recommended for further use.

CancerImmunology Artemisia abyssinica
Orshiso TA et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c01814
PubMed:
37969984

Utilizing network pharmacology and experimental validation to explore the potential molecular mechanisms of raw Pinellia ternate in treating esophageal cancer.

Chinese medicine raw (RP) shows potential therapeutic benefits in treating esophageal cancer. This study used web-based pharmacological methods and cellular experiments to explore its effectiveness as a complementary approach to surgery and radiotherapy.

Cancer Pinellia ternata
Liu Y et al (2023).
J Gastrointest Oncol.
DOI:
10.21037/jgo-23-684
PubMed:
37969842

From seeds to survival rates: investigating Linum usitatissimum's potential against ovarian cancer through network pharmacology.

Data mining, network pharmacology, and molecular docking analysis identified potential phytochemicals for ovarian cancer treatment. Apigenin, Vitamin E, Palmitic acid, Riboflavin, Isolariciresinol, and others were found to suppress tumor growth through biomarker influence. Pharmacokinetics and biosafety require further investigation.

CancerEndocrinology Linum usitatissimum
Islam MM et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1285258
PubMed:
37964873

Network pharmacology to explore the molecular mechanisms of Prunella vulgaris for treating thyroid cancer.

Researchers used network pharmacology and molecular docking techniques to study the therapeutic effects of Prunella vulgaris on thyroid cancer. The findings could provide potential drug targets for treating thyroid cancer.

CancerEndocrinology Prunella vulgaris
Zhang Z et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000034871
PubMed:
37960775
1 62 71 72 73 82 258