Cancer Studies

Phyllanthi Tannin Loaded Solid Lipid Nanoparticles for Lung Cancer Therapy: Preparation, Characterization, Pharmacodynamics and Safety Evaluation.

Researchers developed PTF-loaded solid lipid nanoparticles (PTF-SLNs) for treating lung cancer. PTF-SLNs showed stronger anti-tumor efficacy and reduced harm to normal organs compared to PTF alone. This study offers a potential nanoparticle delivery system to enhance lung cancer treatment.

Wang B et al (2023).
Molecules.
PubMed:
37959818

Emodin-8-O-Glucoside-Isolation and the Screening of the Anticancer Potential against the Nervous System Tumors.

Emodin-8-glucoside, derived from emodin, shows potential as an antitumor compound in neuroblastoma and glioblastoma cells, inhibiting cell viability and proliferation in a dose-dependent manner. It could be a promising therapy for nervous system tumors.

Okon E et al (2023).
Molecules.
PubMed:
37959784

Antioxidant and Antiproliferative Activities of Eclipta prostrata (L.) L. Extract and Isolated Compounds.

A study found that extracts contain two flavonoids with antioxidant properties, particularly in the ethyl acetate extract. The extract also showed potential as an anticancer agent by reducing cell viability and inducing apoptosis.

Yang J et al (2023).
Molecules.
PubMed:
37959773

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice.

Researchers investigated the effects of an immunopotentiator called CPG on the immune response in tumor-bearing mice. Results showed that CPG inhibited tumor growth, enhanced immune responses, and induced tumor cell death. These findings contribute to our understanding of the immune system's role in fighting tumors.

Fan Y et al (2023).
Int J Mol Sci.
PubMed:
37958581

Ultrasound-assisted enzymatic extraction, structural characterization, and anticancer activity of polysaccharides from Rosa roxburghii Tratt fruit.

Extracted from Rosa roxburghii Tratt fruit, polysaccharides RP1 and RP3 induce apoptosis of breast cancer cells. Potential for functional foods or pharmaceutical products for breast cancer treatment.

Jiao X et al (2023).
Int J Biol Macromol.
PubMed:
37956813

Piperlongumine: the amazing amide alkaloid from Piper in the treatment of breast cancer.

Piperlongumine inhibits breast cancer cells, induces apoptosis, and impacts signaling pathways. Its potential in cancer treatment is enhanced by nanotechnology. Future research is needed to understand its chemistry, bioavailability, and toxicity.

Mitra S et al (2023).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
37955690

Analysis of the heavy metal contents' effect on steroidal saponins and the anti-breast cancer activity of Paris polyphylla var. yunnanensis.

The study analyzed the heavy metal content and saponins in a Chinese medicinal plant (var.) used for centuries. They found that high heavy metal content reduced the anti-breast cancer activity. Controlling heavy metal content is important in cultivating var. for medicinal purposes.

Li HL et al (2023).
Front Pharmacol.
PubMed:
37954839

Antiproliferative effect of Solanum nigrum L. water extract on breast can-cer cells: potential roles of apoptosis and oxidative stress.

Solanum nigrum water extract (SNWE) showed significant anticancer effects against MCF-7 and MDA-MB-231 breast cancer cells by inducing apoptotic cell death. This suggests that SNWE could be a potential non-toxic treatment option for breast cancer, but more research is needed.

Khan HA et al (2023).
Cell Mol Biol (Noisy-le-grand).
PubMed:
37953574