Cancer Studies

Hederagenin suppresses ovarian cancer via targeting mitochondrial fission through dynamin-related protein 1.

Hederagenin, a compound from Hedera helix, has anti-cancer, anti-inflammatory, anti-depressant, and anti-fibrosis properties. This study shows that hederagenin suppresses ovarian cancer cell growth, induces apoptosis, alters mitochondrial morphology, and modulates the protein Drp1 to inhibit cancer progression.

Su F et al (2023).
Eur J Pharmacol.
PubMed:
37951490

Allicin extracted from Allium sativum shows potent anti-cancer and antioxidant properties in zebrafish.

Researchers developed a method to extract allicin from garlic and found it remains stable at low temperatures. In zebrafish studies, allicin showed antioxidant, anti-proliferative, apoptotic, and anti-angiogenic properties. This suggests allicin could be investigated as a potential anti-cancer agent.

Ravindra J et al (2023).
Biomed Pharmacother.
PubMed:
37951024

Cytotoxic and anti-metastatic effects of Hypericum perforatum olive oil extract in colorectal cancer cells and human bone marrow derived stem cells.

This study investigated the effects of olive oil extract on colorectal cancer cells and bone marrow-derived stem cells. Results showed reduced cell migration and colony formation, suggesting potential therapeutic benefits against colorectal cancer.

Yildirim H and Daşkan BE (2023).
Nat Prod Res.
PubMed:
37950737

HDAC inhibition by Nigella sativa L. sprouts extract in hepatocellular carcinoma: an approach to study anti-cancer potential.

Scientists studied the 5th day germinated sprouts of seeds for their potential as an anticancer therapy. The sprouts were found to inhibit HDAC activity and have antioxidant properties, making them a promising alternative for preventing liver diseases. Thymoquinone, a compound found in the sprouts, showed strong interaction with HDAC protein.

Algaissi A et al (2023).
J Biomol Struct Dyn.
PubMed:
37948309

Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola.

A study on Averrhoa carambola fruit found it rich in nutrients and vitamins, with higher antioxidant activity and potential health benefits. It could be a valuable source of nutraceutical compounds.

Fragoso AG et al (2023).
Braz J Biol.
PubMed:
37937633

Maackiain suppresses the development of cervical cancer via AMPK priming autophagy.

Maackiain (Mac), a compound from Sophora flavescens, shows potential for treating cervical cancer due to its neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic properties. Further research is needed to confirm its therapeutic benefits.

He J et al (2023).
J Pharm Pharmacol.
PubMed:
37934902