Target Separation and Potential Anticancer Activity of Withanolide-Based Glucose Transporter Protein 1 Inhibitors from Physalis angulata var. villosa.

Researchers discovered a new potential inhibitor of the glucose transporter 1 (GLUT1) protein, called physagulide Y, from the plant Mao-Ku-Zhi. This inhibitor showed strong antitumor activity and could be used to develop targeted cancer treatments.

Zhang J et al (2023).

J Nat Prod.

DOI:

10.1021/acs.jnatprod.3c00613

PubMed:

38117981

A real-world data analysis-based study of Chinese medicine treatment patterns after breast cancer surgery.

The study analyzed breast cancer patients' clinical data after surgery and found that liver depression and spleen deficiency syndrome was common. Common TCM combinations were identified, aiding prescription decision-making post-surgery.

Hu L et al (2023).

Medicine (Baltimore).

DOI:

10.1097/MD.0000000000036642

PubMed:

38115283

Single-cell transcriptome sequencing of plant leaf expressing anti-HER2 VHH-FcK cancer therapeutic protein.

Single-cell RNA sequencing on transgenic tobacco plants expressing a llama antibody against breast cancer reveals gene expression patterns that can improve the selection of cell types for recombinant antibody production in plants.

Kim MS et al (2023).

Sci Data.

DOI:

10.1038/s41597-023-02833-5

PubMed:

38114492

The efficacy and safety of compound kushen injection for adults with esophageal cancer: A meta-analysis of randomized controlled trials.

Researchers investigated the potential anti-cancer properties of Compound Kushen injection (CKI), a medicine used in Chinese traditional medicine. Results suggest CKI may be effective in treating esophageal cancer.

Pan J et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117604

PubMed:

38113988

Mucilage-assisted fabrication of molybdenum trioxide nanostructures for photothermal ablation of breast cancer cells.

Scientists developed a low-cost, green technique to make molybdenum trioxide nanostructures (MNs) using Opuntia ficus-indica mucilage as a template. The MNs, functionalized with folic acid (FA), showed excellent biocompatibility and can be used as an effective photothermal agent to treat breast cancer.

Alomari RA et al (2023).

Biotechnol Appl Biochem.

DOI:

10.1002/bab.2543

PubMed:

38112040

Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis.

Ganoderma lucidum is a Chinese herbal medicine with potential as additional cancer therapy, but its specific effects and mechanisms are still unknown.

Lian S et al (2023).

J Chin Med Assoc.

DOI:

10.1097/JCMA.0000000000001038

PubMed:

38109372

Induction of apoptosis and autophagy by dichloromethane extract from Patrinia scabiosaefolia Fisch on acute myeloid leukemia cells.

Li K et al (2024).

Environ Toxicol.

DOI:

10.1002/tox.24090

PubMed:

38108539

Unraveling the therapeutic potential of Senna singueana phytochemicals to attenuate pancreatic cancer using protein-protein interactions, molecular docking, and MD simulation.

3-methyl-1,8,9-anthracenetriol identified as a potential compound for pancreatic cancer treatment. Further validation required through in-vivo and in-vitro studies.

Balkrishna A et al (2023).

In Silico Pharmacol.

DOI:

10.1007/s40203-023-00179-9

PubMed:

38108042