Cancer Studies

Mechanisms of cancer cell death induction by triptolide: A comprehensive overview.

Triptolide, a component of "Tripterygium Wilfordii," has potential as a cancer therapy. It induces cancer cell death, targets various proteins and pathways, enhances the effectiveness of chemotherapeutics, and can be combined with other therapies to combat toxicities. Exciting advancements are expected in the near future.

Feng K et al (2024).
Heliyon.
PubMed:
38293343

Unveiling the cytotoxic and anti-proliferative potential of green-synthesized silver nanoparticles mediated by Colletotrichum gloeosporioides.

Gupta P et al (2024).
RSC Adv.
PubMed:
38292267

Integration of network pharmacology, molecular docking, and simulations to evaluate phytochemicals from Drymaria cordata against cervical cancer.

This study explores the potential of a natural source for treating cervical cancer. They identified a compound called quercetin 3-O-β-d-glucopyranosyl-(1→2)-rhamnopyranoside as a hit compound that targets proteins responsible for pathway modulations in cervical cancer. Further validation is needed.

Bhattacharya K et al (2024).
RSC Adv.
PubMed:
38292259

Nanoemulsion and nanoencapsulation of a hydroethanolic extract of Nettle (Urtica dioica) and Wormwood (Artemisia absinthium): comparison of antibacterial and anticancer activity.

This study investigated the effects of nanoemulsion and nanoencapsulation of Nettle and Wormwood extracts on antibacterial and anticancer activity. The formulations showed increased activity, especially CCNW, making them potentially useful in food and pharmaceutical industries.

Rahmani Z et al (2024).
Front Chem.
PubMed:
38292020

Bioprocessing of Epothilone B from Aspergillus fumigatus under solid state fermentation: Antiproliferative activity, tubulin polymerization and cell cycle analysis.

Researchers optimized the production of epothilone, a potent anticancer drug, by growing Aspergillus fumigatus on orange peels. The extracted epothilone showed activity against various cancer cells and caused growth arrest in HepG2 cells. This finding suggests a potential commercial source of epothilone.

El-Sayed ASA et al (2024).
BMC Microbiol.
PubMed:
38291363

Discovery of Artemisinins as Microsomal Prostaglandins Synthase-2 Inhibitors for the Treatment of Colorectal Cancer via Chemoproteomics.

Artemisinin, an active compound from a Chinese herb, inhibits colorectal cancer cell growth by targeting microsomal prostaglandins synthase-2, reducing prostaglandin E biosynthesis. This discovery could lead to new treatments for colon cancer.

Geng Y et al (2024).
J Med Chem.
PubMed:
38287228

Antimutagenic and antitumor activities of a water-soluble fraction of soursop (syn Graviola, Annona muricata L.) fruit pulp.

This study analyzed the phenolic content and properties of soursop fruit pulp. It showed antioxidant and antimutagenic properties, as well as cytotoxicity against certain cancer cells. Soursop may have potential as a DNA chemopreventive and antitumor agent.

Scharf RM et al (2024).
J Toxicol Environ Health A.
PubMed:
38285000

Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives.

Researchers found that traditional Chinese medicine (TCM) can effectively manage cancer pain by tonifying, clearing, and activating channels and meridians. This approach may offer a new strategy for alleviating pain without the adverse effects of conventional medications.

Ji J et al (2024).
Am J Chin Med.
PubMed:
38281918