Cancer Studies

Homotherapy-for-heteropathy of Bupleurum Chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer: A network pharmacology and animal model approach.

BS drug pair is effective for depression and tumor treatment, but simultaneous targeting mechanism remains unclear. Understanding could lead to new treatment approaches for both conditions.

Sun R et al (2024).
J Ethnopharmacol.
PubMed:
38479544

Anti-cancer effects of green synthesized gold nanoparticles using leaf extract of Annona muricata. L against squamous cell carcinoma cell line 15 through apoptotic pathway.

Researchers synthesized gold nanoparticles using plant leaf extracts as reducing and capping agents to create safer, targeted therapies for oral cancer. This could offer a promising, less toxic treatment option for tongue squamous cell carcinoma with poor prognosis, particularly in developing nations.

Mary SJ et al (2024).
Dent Res J (Isfahan).
PubMed:
38476717

Atractylenolide II Suppresses Glycolysis and Induces Apoptosis by Blocking the PADI3-ERK Signaling Pathway in Endometrial Cancer Cells.

Atractylenolide II (AT-II) inhibits endometrial cancer cell growth and glycolysis, induces apoptosis by blocking PADI3-ERK pathway. AT-II may be a potential novel therapy for endometrial cancer.

Tian S et al (2024).
Molecules.
PubMed:
38474453

Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management.

TL;DR: Curcumin from turmeric has anti-inflammatory, antioxidant, and potential anticancer effects by interacting with key proteins. Promising for cancer and inflammatory diseases, with growing therapeutic applications.

Moon DO et al (2024).
Int J Mol Sci.
PubMed:
38474160

Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion.

Researchers found that combining magnolol and betulinic acid oil improved their anti-tumor effects, but their low solubility and stability hindered oral bioavailability. This could lead to new methods for cancer treatment.

Zhang H et al (2024).
Drug Dev Ind Pharm.
PubMed:
38466185

Mikania micrantha silver nanoparticles exhibit anticancer activities against human lung adenocarcinoma via caspase-mediated apoptotic cell death.

Green synthesis of silver nanoparticles using leaf extract showed promise in nanotechnology for biomedical applications. The nanoparticles were effective against cancer cells by inducing cytotoxicity, DNA damage, and altering antioxidant enzymes, suggesting potential for cancer therapy.

Lalsangpuii F et al (2024).
Artif Cells Nanomed Biotechnol.
PubMed:
38465883

Efficacy and safety of compound kushen injection for treating advanced colorectal cancer: A protocol for a systematic review and meta-analysis.

Study evaluates effectiveness and safety of Compound Kushen Injection (CKI) combined with chemotherapy for treating advanced colorectal cancer. Shows promise in comprehensive treatment of CRC.

Wu J et al (2024).
Heliyon.
PubMed:
38463847

Banxia-Shengjiang drug pair inhibits gastric cancer development and progression by improving body immunity.

Researchers used network pharmacology to study the Banxia-Shengjiang drug pair's effect on gastric cancer. They identified key target genes like PTGS2 and MMP9, which could be important for inhibiting GC through immune modulation. This study provides insights for potential therapeutic strategies in GC treatment.

Yang Y et al (2024).
Medicine (Baltimore).
PubMed:
38457601