In this study, the researchers investigated the biological functions of Verbascum thapsus methanol extract. They used chromatography and spectrometry to analyze its composition, and tested its antioxidant capacity and cytotoxicity on different cell lines. The extract showed low antioxidant activity but inhibited acetylcholinesterase enzyme.
Water-soluble compounds from plants were tested for their anti-cancer properties against colorectal cancer cells. The most potent compound, L19, showed dose-dependent anti-proliferative activity and induced apoptosis through activation of caspases and inflammatory pathways. L19 can be a starting point for developing new cancer treatments.
The study evaluated the use of a natural cream called Alantel for preventing and treating radiation-induced dermatitis in breast cancer patients. Alantel reduced redness, irritation, and promoted healing of skin lesions. This is important as it provides a potential alternative to pharmacological treatments with fewer side effects.
Chaga mushroom and microalgae extracts showed cytotoxicity against various cancer cell lines. Supercritical water and ethanol-based extracts were most effective, especially when combined. Potential for therapeutic use, but further in vivo studies needed.
Immune checkpoint inhibitors (such as PD-L1/PD-1 blockers) are effective immunotherapy drugs for cancer treatment, but their side effects restrict their use. FDA only permits monoclonal antibody-based PD-L1/PD-1 blockers.
Researchers have discovered that a lectin, PHA, can increase the effectiveness of chemotherapy drugs on lung cancer cells by inhibiting autophagy, promoting apoptosis, and increasing drug concentration inside cells, potentially overcoming drug resistance.
Phytochemicals from plants were screened for their potential as inhibitors of PI3K, a key target in cancer therapy. Beta-spathulene and kaempferol showed promising affinity for PI3K, but further experimental studies are needed for validation.
Ginseng and Ophiopogonin, traditional Chinese herbal pair, enhance immune system in cancer patients. Study identifies main active components and their therapeutic effect on lung cancer.