Cardiology Studies

Dl-3-n-Butylphthalide Improves Stroke Outcomes after Focal Ischemic Stroke in Mouse Model by Inhibiting the Pyroptosis-regulated Cell Death and Ameliorating Neuroinflammation.

NBP reduces brain damage in mice with stroke, improves neurological function, and decreases inflammation. Potential treatment for human ischemic stroke by targeting pyroptosis and neuroinflammation.

Ge M et al (2024).
Eur J Pharmacol.
PubMed:
38636800

Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice.

Gomisin D protects heart cells from damage caused by stress, making it a potential treatment for heart disease. It works by reducing cell death, decreasing heart enzyme levels, and improving energy production in mitochondria.

Chen ZH et al (2024).
J Asian Nat Prod Res.
PubMed:
38634612

Network pharmacology analysis and experimental verification of the antithrombotic active compounds of trichosanthis pericarpium (Gualoupi) in treating coronary heart disease.

Researchers studied the use of Trichosanthis pericarpium in traditional Chinese medicine. TP may help treat symptoms of coronary heart disease by reducing heat, resolving phlegm, promoting Qi, and clearing chest congestion.

Xia KR et al (2024).
J Ethnopharmacol.
PubMed:
38614263

Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments.

Study found honey-processed licorice (HPL) has stronger heart protection than raw licorice. Material basis and mechanism still unclear. Relevant for clinical use of traditional Chinese herb.

Sun P et al (2024).
J Ethnopharmacol.
PubMed:
38604511

Enhancing the therapeutic potential of isoliensinine for hypertension through PEG-PLGA nanoparticle delivery: A comprehensive in vivo and in vitro study.

Scientists developed PEG-PLGA nanoparticles loaded with isoliensinine to improve its antihypertensive efficacy. This could lead to better treatment options for hypertension, a common and damaging chronic disease.

Yao M et al (2024).
Biomed Pharmacother.
PubMed:
38565063

Association between habitual betel quid chewing and risk of adverse cardiovascular outcomes: A systematic review.

Betel quid chewing is linked to oral cancer in Asia-Pacific. Research examines if it also causes cardiovascular issues. Understanding this can lead to better health recommendations.

Itaki R and Taufa S (2024).
Trop Med Int Health.
PubMed:
38556799

Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate-protein kinase G signaling in diabetic mice.

Researchers studied the potential benefits of Polygonatum sibiricum polysaccharide (PSP) in treating diabetic cardiomyopathy (DCM) in mice. Results may lead to new treatments for this common condition in diabetic individuals.

Lei S et al (2024).
J Diabetes Investig.
PubMed:
38553792

Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension.

Plant-derived inorganic nitrate did not improve vascular function or blood pressure in older adults with hypertension, casting doubt on the efficacy of nitrate-based interventions for healthy aging.

Fejes R et al (2024).
Food Funct.
PubMed:
38546454