The Huangxiong Formula, made up of four herbs, is used to treat ischemic stroke, but scientists do not yet understand how it works on a molecular level.
Gastrodia elata Blume (Tianma) is used in Chinese medicine to treat various disorders. Its compounds show potential for neuroprotection, pain relief, anxiety, depression, blood pressure control, liver protection, anti-tumor effects, and immunity enhancement in cardiovascular diseases.
Gelsevirine reduces stroke damage by decreasing inflammation and apoptotic cells, improving neurobiological function, and downregulating microglia activity and JAK-STAT signal pathway.
This study identified active ingredients in the medicinal herb L. (Gokshura) that have potential to treat cardiac diseases. The compounds include Kaempferol 3-rutinoside 7-glucuronide, rutin, and quercetin-3-o-α-rhamnoside. Further research is needed to assess efficacy.
Nigella sativa shows promise as a treatment for ischemic stroke due to its therapeutic properties and presence of thymoquinone, potentially offering a complementary therapy for patients and exploring preventive and treatment possibilities.
The study found that ellagic acid (EA) and punicic acid (PA) reduced pro-fibrotic proteins, reactive oxygen species, and inflammation in cardiac fibroblasts. EA and PA could be effective in reducing fibrosis.
The study investigated the effects of DHT on ischemic stroke. DHT is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, that has various pharmacological effects. The study found that DHT has a protective effect against ischemic stroke by increasing Nrf2 expression. Nrf2 is a key regulator of antioxidative stress responses and is associated with ferroptosis inhibition, a process involved in stroke. These findings suggest that DHT has therapeutic potential for the treatment of ischemic stroke.
Recreational use of certain cannabinoid agonists in herbal blends can cause cardiovascular events. JWH-073 may have greater vascular adverse effects than Δ-THC.