Cardiology Studies

Unveiling Alternative Oxidation Pathways and Antioxidant and Cardioprotective Potential of Amaranthin-Type Betacyanins from Spinach-like Atriplex hortensis var. 'Rubra'.

Advanced analytical techniques were used to investigate the oxidation mechanism of betacyanins. Alternative pathways and antioxidant oxidation products were discovered, with potential protective effects against cell death, providing insights into the biological activities of these compounds.

CardiologyImmunology Spinacia oleracea
Kumorkiewicz-Jamro A et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c03044
PubMed:
37791532

Reversing the escape from herbivory: Knockout of cardiac glycoside biosynthesis in wormseed wallflower ( Erysimum cheiranthoides L., Brassicaceae).

Wallflowers produce glucosinolates and cardiac glycosides to defend against herbivores. Knocking out enzymes involved in cardiac glycoside biosynthesis makes them susceptible to herbivory. Specialist herbivores are unable to feed on wallflowers without cardiac glycosides.

CardiologyPhytochemistry Erysimum cheiranthoides
Younkin GC et al (2023).
bioRxiv.
DOI:
10.1101/2023.09.19.558517
PubMed:
37790475

Heart rot disease of walnut caused by Nothophoma juglandis sp. nov. and its endophytic biocontrol agent.

A new fungus, identified in walnut plantations in Beijing, causes heart rot disease in walnut trees. Another fungus, co-isolated with the new species, acts as a biocontrol agent, inhibiting the spread of the disease. The optimal temperature for both fungi's growth and pathogenicity is common in Chinese walnut growing regions.

Cardiology Juglans regia
Zhao L et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-11-22-2660-RE
PubMed:
37787687

Study on network pharmacology of Ginkgo biloba extract against ischaemic stroke mechanism and establishment of UPLC-MS/MS methods for simultaneous determination of 19 main active components.

Ginkgo biloba extract (GBE) is effective for treating stroke, but we don't know the active ingredients or how it works. You should care because understanding its mechanism can help us develop better treatments.

CardiologyNeuroscience Ginkgo biloba
Yin CY et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3286
PubMed:
37758241

Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia-reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2/HO-1 signaling pathway.

This study looked at how a polysaccharide from Gastrodia elata called NPGE affects the interaction between ferroptosis and neuroinflammation during cerebral ischemia-reperfusion injury. It found that NPGE has potential effects against oxidative stress and inflammation in CIRI neuropathology.

CardiologyNeuroscience Gastrodia elata
Zhang Y et al (2023).
CNS Neurosci Ther.
DOI:
10.1111/cns.14456
PubMed:
37752806

Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation.

Banxia baizhu tianma decoction (BBTD) is a traditional Chinese medicine with a long history of use for treating excessive phlegm-dampness hypertension. However, the specific effects of each herb in BBTD are unclear, limiting its full understanding and potential for hypertension treatment.

Cardiology Gastrodia elataPinellia ternata
Zhang H et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117193
PubMed:
37726069

Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.

Tangeretin (found in Citrus reticulata peel) protects against cerebral ischemia and reperfusion (I/R) injury by inhibiting neuronal pyroptosis via the AIM2 inflammasome and regulating NRF2. TANG could be a potential therapy for I/R injury.

CardiologyNeuroscience Citrus reticulata
You G et al (2023).
Inflammation.
DOI:
10.1007/s10753-023-01900-8
PubMed:
37725272

Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury.

Scientists studied the impact of herbal medicines on stroke management. Current therapies have limited effectiveness, but herbal medicines could improve outcomes by modulating neuroplasticity. This research addresses the need for novel strategies for stroke treatment.

Cardiology Curcuma longa
Bangar A et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117153
PubMed:
37717842
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